Yang et al report that intrinsic cardiac adrenergic cell-derived norepinephrine promotes myocardial dysfunction in response to LPS. They demonstrate norepinephrine produced by these cells activated β1-adrenergic receptors on cardiomyocytes increasing the expression of tumor necrosis factor-a in a Ca2+/calmodulin-dependent protein kinase II dependent manner.
- Duomeng Yang
- Xiaomeng Dai
- Huadong Wang
