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Nature Communications (3)
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Showing 1–5 of 5 results

Advanced filters: Author: Xianle Shi Clear advanced filters

WDR5 remodels NANOG condensates to drive transcriptional programs and sustain stem cell identity

This study shows that WDR5 remodels NANOG condensates to control transcriptional programs. Disrupting their interaction compromises stem cell identity and suppresses leukemia stem cell expansion.

Duo Wang
Xianle Shi
Yanjing Li
ResearchOpen Access21 Jan 2026
Nature Communications

P: 1-19
DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells

Pluripotent stem cells depend on specialized nuclear organization for their function. Here, the authors show that DDX18 regulates nucleolar phase separation and chromatin architecture to preserve human embryonic stem cell pluripotency.

Xianle Shi
Yanjing Li
Jianlong Wang
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-21
Pluripotency factor Tex10 finetunes Wnt signaling for spermatogenesis and primordial germ cell development

Here they identify Tex10 as a critical regulator of male fertility and germ cell development. By fine-tuning Wnt signaling, Tex10 promotes spermatogenesis and PGC differentiation, offering potential therapeutic insights for treating male infertility.

Feifei Yuan
Jihong Yang
Jianlong Wang
ResearchOpen Access23 Feb 2025
Nature Communications

Volume: 16, P: 1-22
RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells

The authors show that TET2 is recruited to chromatin by the RNA-binding protein PSPC1. PSPC1 and TET2 contribute to ERV and ERV-associated gene regulation by both transcriptional repression via histone deacetylases and post-transcriptional destabilization of ERV RNAs through 5hmC modification.

Diana Guallar
Xianju Bi
Jianlong Wang
Research26 Feb 2018
Nature Genetics

Volume: 50, P: 443-451
LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma

Xiukun Hou
Xianle Shi
Ming Gao
ResearchOpen Access01 Apr 2021
Cell Death & Disease

Volume: 12, P: 1-18