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Advanced filters: Author: Xiao-Ling Cockcroft Clear advanced filters

  • A chemical probe BI-9321 for the PWWP1 domain of NSD3 and its inactive analog were identified. BI-9321 binds to the methyl-lysine binding site, reduces the association of NSD3 with chromatin and inhibits proliferation of acute myeloid leukemia cells.

    • Jark Böttcher
    • David Dilworth
    • Darryl B. McConnell
    Research
    Nature Chemical Biology
    Volume: 15, P: 822-829