Measuring the levels of circulating SARS-CoV-2 RNA in plasma might represent a more accurate way to detect lower respiratory tract and extrapulmonary infections, which classical COVID-19 detection assays based on nasopharyngeal swabs might miss. Here, the authors accurately detect SARS-CoV-2 RNA in plasma-circulating extracellular vesicles using a CRISPR–Cas-based strategy that shows promising characteristics for potential clinical application.
- Bo Ning
- Zhen Huang
- Tony Y. Hu
