The prostate is an important part of the male reproductive system whose aging process is incompletely understood. Sun et al. identify GRHL2 downregulation as a driver of prostate aging. They show that GRHL2 transactivates CDK19 to inhibit p53−p21 signaling and demonstrate that GRHL2 gene therapy alleviates age-related urinary dysfunction in mice.
- Guoqiang Sun
- Zan He
- Guang-Hui Liu
