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Author Correction: Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development

Chenfei Wang
Xiaoyu Liu
Shaorong Gao
Amendments and Corrections14 Oct 2025
Nature Cell Biology

Volume: 27, P: 2240
Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis

Li, He, Liu and colleagues characterize the dynamic bivalent chromatin landscape during mouse peri-implantation development. They find that factor ZBTB17 works with KDM6A/B to resolve transiently maintained bivalent domains and prime gene activation.

Yanhe Li
Jincan He
Wenqiang Liu
Research01 Oct 2025
Nature Cell Biology

Volume: 27, P: 1797-1811
LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei

Asymmetric histone modifications in parental pronuclei displays epigenetic regulation. Here the authors reveal the role of LSM1-mediated Major Satellite RNA decay in the H3 variant incorporation and modifications in male pronucleus.

Jiang Zhu
Kang Chen
Lan Kang
ResearchOpen Access21 Feb 2023
Nature Communications

Volume: 14, P: 1-16
N⁶-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition

Wu et al. optimized the m⁶A mapping method for ultralow-input materials and characterized the transcriptome-wide landscape of m⁶A methylation in mouse oocytes and early embryos.

You Wu
Xiaocui Xu
Shaorong Gao
Research23 May 2022
Nature Cell Biology

Volume: 24, P: 917-927
Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation

Injecting Cas9 and gRNA into an animal zygote often produces mosaicism and random biallelic targeting. Here, the authors use pronuclear transfer to reduce mosaicism and selectively target parental alleles.

Yanhe Li
Yuteng Weng
Shaorong Gao
ResearchOpen Access14 Sept 2020
Nature Communications

Volume: 11, P: 1-12
Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos

The organisation of chromatin in somatic cell nuclear transfer (SCNT) embryos remains poorly understood. Here, the authors examine higher order chromatin structures of mouse SCNT embryos and provide insights into chromatin architecture reorganisation during SCNT embryo development.

Mo Chen
Qianshu Zhu
Shaorong Gao
ResearchOpen Access14 Apr 2020
Nature Communications

Volume: 11, P: 1-14
Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos

H3K9me3 is an epigenetic barrier to the reprogramming of somatic cells to a totipotent state during somatic cell nuclear transfer. Here, the authors uncover molecular mechanisms regulating H3K9me3 modifications in this process.

Ruimin Xu
Qianshu Zhu
Xiaoyu Liu
ResearchOpen Access09 Aug 2023
Nature Communications

Volume: 14, P: 1-15
Unique features of mutations revealed by sequentially reprogrammed induced pluripotent stem cells

Mice can be generated from induced pluripotent stem cells (iPSCs) but the impact of accumulated mutations on the developmental potential of the cells remains to be determined. Here the authors show that mice generated from iPSCs tolerate the accumulation of somatic mutations for up to six generations, but their viability decreased with increasing generations.

Shuai Gao
Caihong Zheng
Shaorong Gao
Research18 Feb 2015
Nature Communications

Volume: 6, P: 1-10
Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer

Here the authors find that farrerol directly binds to UCHL3 and activates its deubiquitinase activity, and that farrerol promotes development of SCNT embryos by enhancing HR repair and restoring epigenetic networks in a UCHL3-dependent manner.

Weina Zhang
Mingzhu Wang
Ying Jiang
ResearchOpen Access03 Apr 2023
Nature Communications

Volume: 14, P: 1-17
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos

Three papers in this issue of Nature use highly sensitive ChIP–seq assays to describe the dynamic patterns of histone modifications during early mouse embryogenesis, showing that oocytes have a distinctive epigenome and providing insights into how the maternal gene expression program transitions to the zygotic program.

Xiaoyu Liu
Chenfei Wang
Shaorong Gao
Research14 Sept 2016
Nature

Volume: 537, P: 558-562
CRISPR/Cas9-mediated genome engineering of the ferret

Zhaohui Kou
Qian Wu
Xiaoqun Wang
CorrespondenceOpen Access13 Nov 2015
Cell Research

Volume: 25, P: 1372-1375
Allelic reprogramming of the histone modification H3K4me3 in early mammalian development

Three papers in this issue of Nature use highly sensitive ChIP–seq assays to describe the dynamic patterns of histone modifications during early mouse embryogenesis, showing that oocytes have a distinctive epigenome and providing insights into how the maternal gene expression program transitions to the zygotic program.

Bingjie Zhang
Hui Zheng
Wei Xie
Research14 Sept 2016
Nature

Volume: 537, P: 553-557
Modeling post-gastrula development via bidirectional pluripotent stem cells

Kuisheng Liu
Zihui Yan
Wenqiang Liu
Research29 Aug 2025
Cell Research

Volume: 35, P: 954-969
Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development

Gao and colleagues characterize genome-wide H3K9me3 distributions in pre- and post-implantation mouse embryos, providing a resource to further our understanding of epigenomic dynamics during mammalian embryogenesis.

Chenfei Wang
Xiaoyu Liu
Shaorong Gao
Research23 Apr 2018
Nature Cell Biology

Volume: 20, P: 620-631
Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation

Chenfei Wang
Chuan Chen
Shaorong Gao
ResearchOpen Access15 Apr 2022
Cell Research

Volume: 32, P: 801-813
Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing

Wenqiang Liu
Xiaoyu Liu
Shaorong Gao
ResearchOpen Access07 Jun 2016
Cell Discovery

Volume: 2, P: 1-15
Precise temporal regulation of Dux is important for embryo development

Mingyue Guo
Yanping Zhang
Yixuan Wang
Correspondence07 Oct 2019
Cell Research

Volume: 29, P: 956-959
High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells

Gang Chang
Shuai Gao
Jianhui Tian
Research31 Dec 2013
Cell Research

Volume: 24, P: 293-306

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Author Correction: Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development

Remodelling bivalent chromatin is essential for mouse peri-implantation embryogenesis

LSM1-mediated Major Satellite RNA decay is required for nonequilibrium histone H3.3 incorporation into parental pronuclei

N⁶-methyladenosine regulates maternal RNA maintenance in oocytes and timely RNA decay during mouse maternal-to-zygotic transition

Precise allele-specific genome editing by spatiotemporal control of CRISPR-Cas9 via pronuclear transplantation

Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos

Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos

Unique features of mutations revealed by sequentially reprogrammed induced pluripotent stem cells

Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer

Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos

CRISPR/Cas9-mediated genome engineering of the ferret

Allelic reprogramming of the histone modification H3K4me3 in early mammalian development

Modeling post-gastrula development via bidirectional pluripotent stem cells

Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development

Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation

Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing

Precise temporal regulation of Dux is important for embryo development

High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells

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