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Showing 1–6 of 6 results
Advanced filters: Author: Xin-Shan Ye Clear advanced filters

  • The complexity of carbohydrate structures makes their synthesis challenging. Now, an automated glycan synthesizer is reported which is capable of preparing a library of bioactive oligosaccharides, including a fully protected fondaparinux pentasaccharide. Furthermore, the synthesizer can rapidly assemble arabinans up to 1,080-mer size, starting from monosaccharide building blocks.

    • Wenlong Yao
    • De-Cai Xiong
    • Xin-Shan Ye
    Research
    Nature Synthesis
    Volume: 1, P: 854-863

  • Visible light-induced glycosylation reactions are achieved by either photoactivating a photosensitizer or using a stoichiometric activator, while glycosylation via a photoactive glycosyl donor was so far not reported. In this study, the authors develop a photosensitizer free visible-light-mediated glycosylation approach using photoactive 2-glycosyloxy tropone as the donor, obtaining a wide range of O-glycosides or oligosaccharides.

    • Jing Zhang
    • Zhao-Xiang Luo
    • De-Cai Xiong
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Due to the vast number of potential isomers, the chemical synthesis of large carbohydrates is challenging. Here the authors report the synthesis of mycobacterial arabinogalactan, a biologically important natural product composed of 92 monosaccharide units, the largest synthetic polysaccharide to date.

    • Yong Wu
    • De-Cai Xiong
    • Xin-Shan Ye
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7

  • Fucoidan is a sulfated glycan with anticoagulant properties, but its structural complexity and heterogeneity hinders understanding of its structure-activity relationship. Here, the authors synthesize a diverse library of 58 distinct fucoidans with multiple contiguous 1,2-cis glycosidic bonds and various sulfation patterns, and investigate their anticoagulant activity.

    • Si-Cong Chen
    • Xianjin Qin
    • Xin-Shan Ye
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Arabinogalactan RN1 displays potent anti-pancreatic-cancer activity; however, the structure–activity relationship of RN1 is unclear. Now the synthesis of RN1 and a library of glycans are reported, using an iterative preactivation-based one-pot glycosylation strategy. Biological analysis reveals that a decasaccharide is the active structural domain of RN1.

    • Xianjin Qin
    • Chenghao Xu
    • Xin-Shan Ye
    Research
    Nature Synthesis
    Volume: 3, P: 245-255