Functionalized cyclobutanes are prized motifs in pharmaceutically active molecules, but due to the ring strain involved, their syntheses have been associated with lots of challenges. Here the authors present a methodology to transform cyclobutanols, which are relatively easily prepared, to cyclobutanecarboxamides via palladium catalysis.
- Xing-Wei Gu
- Yan-Hua Zhao
- Xiao-Feng Wu
