Nature Search

R-loops orchestrate RNAPII transcriptional reprogramming for the maternal-to-zygotic transition

Yaoyi Li
Qing Li
Hongjie Yao
Research09 Jan 2026
Cell Research

P: 1-16
Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility

Integrating genetic information with circulating proteomics can help understand mechanisms of disease. Here, the authors conduct genome-wide association analyses of the serum proteome in 2,958 Han Chinese individuals, uncovering proteins which may contribute to ancestry differences in cardiometabolic disease susceptibility.

Fengzhe Xu
Evan Yi-Wen Yu
Ju-Sheng Zheng
ResearchOpen Access16 Feb 2023
Nature Communications

Volume: 14, P: 1-12
Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population

Ranran Kang
Ping Li
Xiao-Fen Chen
ResearchOpen Access28 Jan 2016
Scientific Reports

Volume: 6, P: 1-8
Graph-based pan-genome reveals structural and sequence variations related to agronomic traits and domestication in cucumber

Increasing studies have suggested that single reference genome is insufficient to capture all variations in the genome. Here, the authors report a graph-based cucumber pan-genome by analyzing 12 chromosome-scale assemblies and reveal variations associated with agronomic traits and domestication.

Hongbo Li
Shenhao Wang
Zhonghua Zhang
ResearchOpen Access03 Feb 2022
Nature Communications

Volume: 13, P: 1-14
Hypertensive disorders of pregnancy and risks of adverse pregnancy outcomes: a retrospective cohort study of 2368 patients

Xun Li
Weishe Zhang
Si Duan
Research17 Feb 2020
Journal of Human Hypertension

Volume: 35, P: 65-73
Proteogenomic analysis reveals Arp 2/3 complex as a common molecular mechanism in high risk pancreatic cysts and pancreatic cancer

A. K. M. Firoj Mahmud
Dina Gamaleldin Mansour Aly
Xinxiu Li
ResearchOpen Access31 Jan 2025
Scientific Reports

Volume: 15, P: 1-13
Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells

Quan Wang
Xinxiu Xu
Xin Xie
ResearchOpen Access05 Jul 2011
Cell Research

Volume: 21, P: 1424-1435
Multiomics biomarkers were not superior to clinical variables for pan-cancer screening

Smelik et al. investigate the effectiveness of using multi-omics biomarkers in blood for cancer screening. The results indicate that while these biomarkers show promise for diagnosing individual cancers in close proximity to the blood stream, they do not surpass clinical variables for diagnosing multiple cancers.

Martin Smelik
Yelin Zhao
Mikael Benson
ResearchOpen Access17 Nov 2024
Communications Medicine

Volume: 4, P: 1-8
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study

Yan Gao
Haixia He
Huiqiang Huang
ResearchOpen Access17 May 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-9
Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening

Lin et al. find that mutation in endocytic trafficking protein Lrp1 causes congenital heart defects in mice due to a requirement for Lrp1 in the neural crest lineage, where it regulates outflow tract lengthening. This study provides insights into how Lrp1 and the neural crest contribute to heart development.

Jiuann-Huey I. Lin
Timothy N. Feinstein
Cecilia W. Lo
ResearchOpen Access16 Jun 2020
Communications Biology

Volume: 3, P: 1-12
Targeting ERK induced cell death and p53/ROS-dependent protective autophagy in colorectal cancer

Wunan Mi
Chuyue Wang
Yang Fu
ResearchOpen Access04 Dec 2021
Cell Death Discovery

Volume: 7, P: 1-11
An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases

Martin Smelik
Yelin Zhao
Mikael Benson
ResearchOpen Access03 Jun 2024
Scientific Reports

Volume: 14, P: 1-10
An algorithm-based meta-analysis of genome- and proteome-wide data identifies a combination of potential plasma biomarkers for colorectal cancer

Danuta R. Gawel
Eun Jung Lee
Mikael Benson
ResearchOpen Access30 Oct 2019
Scientific Reports

Volume: 9, P: 1-12

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