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Showing 1–1 of 1 results
Advanced filters: Author: Xiong-Ping Chen Clear advanced filters

  • The transcriptional repressor Blimp-1 has an important role in B-cell differentiation. Here the authors show that lymphoma-associated Blimp-1 mutants are selectively recognized by HSP70-Hrd1, which leads to their accelerated degradation and propose HSP70 inhibition as a therapeutic approach for certain lymphomas.

    • Wen-Fang Wang
    • Li Yan
    • Jiang Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16