Nature Search

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Author Correction: Mapping global lake dynamics reveals the emerging roles of small lakes

Xuehui Pi
Qiuqi Luo
Brett A. Bryan
Amendments and CorrectionsOpen Access25 Oct 2022
Nature Communications

Volume: 13, P: 1
The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions: insights from a single-arm, phase II trial

Bo Cheng
Caichen Li
Wenhua Liang
ResearchOpen Access19 Apr 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-13
An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness

Activated Notch signalling promotes cancer metastasis and stemness. Here the authors show that Notch1 activates transcription of DNA replication factor RCF4 and that RCF4 binds and stabilises Notch1 intracellular domain (NICD1) to promote cancer metastasis.

Lei Liu
Tianyu Tao
Han Tian
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-16
Mapping global lake dynamics reveals the emerging roles of small lakes

Lakes are essential components of the hydrological and biogeochemical cycles. Here, Pi et al develop a global lake dataset called GLAKES via high-resolution satellite images and deep learning to examine global lake changes over four decades.

Xuehui Pi
Qiuqi Luo
Brett A. Bryan
ResearchOpen Access01 Oct 2022
Nature Communications

Volume: 13, P: 1-12
Groundwater-surface interaction amplified post-seismic streamflow fluctuation

The 2014 South Napa earthquake in California caused increased streamflow and diurnal fluctuations in Sonoma Creek due to amplified interaction between rising water table and plant roots in the riparian zone, according to results from numerical simulations constrained by streamflow record and hydraulic properties of the riparian sediments.

Chi-Yuen Wang
Lee-Ping Wang
Xiuyu Liang
ResearchOpen Access22 Oct 2024
Communications Earth & Environment

Volume: 5, P: 1-8
Achievement splitting for topological states with pseudospin in phase modulation by using gyromagnetic photonic crystals

Liu He
Yuting Yang
Jianquan Yao
ResearchOpen Access27 Jul 2024
Scientific Reports

Volume: 14, P: 1-9
Porcine intraepithelial lymphocytes undergo migration and produce an antiviral response following intestinal virus infection

When piglets are infected with intestinal virus, porcine intraepithelial lymphocytes undergo intra-and trans-epithelial migration promoted by chemokines from infected epithelial cells and produce an antiviral response.

Yuchen Li
Yichao Ma
Qian Yang
ResearchOpen Access22 Mar 2022
Communications Biology

Volume: 5, P: 1-16
HBx-induced S100A9 in NF-κB dependent manner promotes growth and metastasis of hepatocellular carcinoma cells

Liang Duan
Rui Wu
Weixian Chen
ResearchOpen Access24 May 2018
Cell Death & Disease

Volume: 9, P: 1-14

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