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Showing 1–5 of 5 results

Advanced filters: Author: Xuewu Sui Clear advanced filters

Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis

Sui et al. elucidate the mechanisms of action for small molecule inhibitors of human triacylglycerol synthesis enzyme DGAT1 and provide insights into how these inhibitors achieve selectivity for DGAT1 rather than other closely related MBOAT enzymes.

Xuewu Sui
Kun Wang
Tobias C. Walther
ResearchOpen Access29 May 2023
Nature Communications

Volume: 14, P: 1-10
The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification

Wang et al. report a structure for human MBOAT7, the enzyme responsible for remodeling acyl chains of phosphatidylinositol. The structure enabled the identification of MBOAT7 inhibitors and provides insights into substrate specificity among MBOATs.

Kun Wang
Chia-Wei Lee
Robert V. Farese Jr
ResearchOpen Access14 Jun 2023
Nature Communications

Volume: 14, P: 1-14
Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme

Cryo-electron microscopy structures and functional and mutagenesis studies provide insights into the catalysis of triacylglycerol synthesis by human acyl-CoA diacylglycerol acyltransferase at its intramembrane active site.

Xuewu Sui
Kun Wang
Robert V. Farese Jr
Research13 May 2020
Nature

Volume: 581, P: 323-328
Seipin forms a flexible cage at lipid droplet formation sites

Arlt et al. report a structure of yeast seipin, a lipid droplet formation protein, and suggest that it forms a flexible, oligomeric cage in the endoplasmic reticulum membrane, enabling triacylglycerol phase separation, lipid droplet growth and budding toward the cytoplasm.

Henning Arlt
Xuewu Sui
Tobias C. Walther
ResearchOpen Access24 Feb 2022
Nature Structural & Molecular Biology

Volume: 29, P: 194-202
Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

Retinoid isomerase is a critical enzyme in the conversion of retinyl esters to 11-cis-retinol, a key step in the regeneration of visual pigments that mediate light perception. Structural, biochemical and modeling data using substrate analogs explain how this unusual reaction proceeds.

Philip D Kiser
Jianye Zhang
Krzysztof Palczewski
Research20 Apr 2015
Nature Chemical Biology

Volume: 11, P: 409-415