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Advanced filters: Author: Xunhao Xiong Clear advanced filters

  • The mitochondrial uniporter MICU1 regulates mitochondrial Ca2+ uptake. Here, the authors show that MICU1 is upregulated in ovarian cancer and confers resistance to cisplatin-induced apoptosis through a Ca2+-mediated regulation of pyruvate dehydrogenase activity that results in increased glycolysis.

    • Prabir K. Chakraborty
    • Soumyajit Banerjee Mustafi
    • Priyabrata Mukherjee
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16