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Showing 1–5 of 5 results
Advanced filters: Author: Y. Chakrapani Clear advanced filters

  • Exportin-1 (XPO1) was identified as the target of small molecules suppressing T cell activation. Selective disruption of the chromatin scaffolding function of XPO1 without blocking nuclear export implicates XPO1 as a target in autoimmunity.

    • Yi Fan Chen
    • Maryam Ghazala
    • Drew J. Adams
    Research
    Nature Chemical Biology
    Volume: 20, P: 1260-1271

  • The cryo-EM structure of the full-length TRPV5 channel in complex with inhibitor econazole reveals a domain-swapped architecture and provides insights into mechanisms of inhibition.

    • Taylor E. T. Hughes
    • David T. Lodowski
    • Vera Y. Moiseenkova-Bell
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 53-60

  • Transient receptor potential (TRP) proteins are Ca2+-permeable cation channels activated by a range of chemical and physical stimuli. Here the authors describe a cryo-EM structure of the full-length TRPV2 channel that provides insight into the regulation of the TRPV subfamily of channels.

    • Kevin W. Huynh
    • Matthew R. Cohen
    • Vera Y. Moiseenkova-Bell
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8

  • TRPV5 is a kidney specific transient receptor potential (TRP) channel with an important role in calcium reabsorption. Here the authors provide mechanistic insights into TRPV5 modulation by determining the phosphatidylinositol 4,5-bisphosphate and calmodulin bound TRPV5 cryo-EM structures.

    • Taylor E. T. Hughes
    • Ruth A. Pumroy
    • Vera Y. Moiseenkova-Bell
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11