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Advanced filters: Author: Ya-Cheng Liao Clear advanced filters

Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity

Neurodegenerative disorders remain poorly treated despite their growing disease burden. Here, authors developed a multiplexed screening platform that identified DNAJB6 as a modulator of condensate maturation and suppressor ALS/FTD-linked toxicity.

Samuel J. Resnick
Seema Qamar
Alejandro Chavez
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-27
Secretome translation shaped by lysosomes and lunapark-marked ER junctions

Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lunapark protein and is modulated by nutrient status.

Heejun Choi
Ya-Cheng Liao
Jennifer Lippincott-Schwartz
ResearchOpen Access05 Nov 2025
Nature

Volume: 649, P: 227-236
Transverse writing of three-dimensional tubular optical waveguides in glass with a slit-shaped femtosecond laser beam

Yang Liao
Jia Qi
Ya Cheng
ResearchOpen Access27 Jun 2016
Scientific Reports

Volume: 6, P: 1-6
Fabrication of polarization-independent waveguides deeply buried in lithium niobate crystal using aberration-corrected femtosecond laser direct writing

Peng Wang
Jia Qi
Ya Cheng
ResearchOpen Access23 Jan 2017
Scientific Reports

Volume: 7, P: 1-6

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