TRIM5α is known to restrict HIV-1 reverse transcription. Here, Ran et al. report that TRIM5α recruits HDAC1 to NF-κB p50, Sp1, and HIV-1 LTR, and promotes H3K9 deacetylation at the HIV-1 LTR, leading to TNFα-induced HIV-1 LTR-driven expression.
- Xiang-Hong Ran
- Jia-Wu Zhu
- Dan Mu
