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Showing 1–6 of 6 results
Advanced filters: Author: Yaara Finkel Clear advanced filters

  • Here, Israeli and Finkel et al. perform genome-wide CRISPR knockout screens to identify host factors required for the infection with SARS-CoV-2 and two additionally variants of concern, Alpha and Beta, unveiling shared and differential host pathways required by the variants, and demonstrate GATA6 is critical for SARS-CoV-2 viral entry through modulation of ACE2 expression.

    • Ma’ayan Israeli
    • Yaara Finkel
    • Adi Bercovich-Kinori
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • HCMV infection can become productive or latent. Here the authors show that variations in the number of incoming viral particles across cell types is a key factor of this decision, identifying entry efficiency as a key regulator of latency.

    • Yaarit Kitsberg
    • Aharon Nachshon
    • Michal Schwartz
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • RNA sequencing, ribosome profiling and metabolic labelling of newly synthesized RNA reveal the strategy used by SARS-CoV-2 to shut off cellular protein synthesis in the host and allow the translation of viral transcripts.

    • Yaara Finkel
    • Avi Gluck
    • Noam Stern-Ginossar
    Research
    Nature
    Volume: 594, P: 240-245

  • A high-resolution map of coding regions in the SARS-CoV-2 genome enables the identification of 23 unannotated open reading frames and quantification of the expression of canonical viral open reading frames.

    • Yaara Finkel
    • Orel Mizrahi
    • Noam Stern-Ginossar
    Research
    Nature
    Volume: 589, P: 125-130

  • In the virus-encoded CRISPR-based direct readout system, single-guide RNA libraries are expressed directly from the genomes of viruses so that single-guide RNA abundance at distinct stages of the viral infection cycle provides direct and quantitative readout of gene-perturbation effects on viral propagation.

    • Anna Lilja
    • Yaara Finkel
    • Noam Stern-Ginossar
    Protocols
    Nature Protocols
    Volume: 21, P: 1429-1465

  • A genetic screen that expresses single guide RNA libraries targeting host genes in the human cytomegalovirus genome enables identification of host factors and provides insights into their roles during the viral replication cycle.

    • Yaara Finkel
    • Aharon Nachshon
    • Noam Stern-Ginossar
    Research
    Nature
    Volume: 630, P: 712-719