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Showing 1–5 of 5 results
Advanced filters: Author: Yael B Kushner Clear advanced filters

  • This article considers the case of a 73-year-old white man who presented with synchronous gastric carcinomas and a 20-year history of mixed polyposis. Genetic-testing and molecular-pathology analyses confirmed a diagnosis of Cowden's syndrome. The case explores the diagnostic challenges of differentiating between hamartomatous and adenomatous polyposis syndromes in patients with mixed polyposis, and emphasizes the need to characterize the risk of gastrointestinal cancer in patients with this syndrome.

    • Khalid Al-Thihli
    • Laura Palma
    • William D Foulkes
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 6, P: 184-189

  • Lasting complete remission from widespread bone metastases is rare. The case of a 41-year-old premenopausal woman diagnosed with right-sided infiltrating ductal breast carcinoma andBRCA2mutation is described. She received high-dose anthracycline-based induction chemotherapy followed by autologous bone marrow transplantation with high-dose alkylator and platin-based conditioning regimens. The authors comment on the reasons for this unusual and sustained complete remission from widely metastatic breast cancer and the patient-specific factors that may have contributed to this outcome.

    • Fleur Huang
    • Yael B. Kushner
    • William D. Foulkes
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 6, P: 488-492

  • Social encounters are associated with varying degrees of stress. The authors show that modulation of stress system components in the medial amygdala alters preference for familiar vs. novel conspecifics. Inhibition of the relevant circuit in a group of familiar mice kept under semi-natural conditions increased pro-social behavior.

    • Yair Shemesh
    • Oren Forkosh
    • Alon Chen
    Research
    Nature Neuroscience
    Volume: 19, P: 1489-1496