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Showing 1–10 of 10 results
Advanced filters: Author: Yael Goldfarb Clear advanced filters

  • Multiomic analyses of mouse thymic epithelial cells identify several unconventional subsets that are mimetics of various populations of terminally differentiated parenchymal cells and provide insights into their development, molecular features and function.

    • Tal Givony
    • Dena Leshkowitz
    • Jakub Abramson
    Research
    Nature
    Volume: 622, P: 164-172

  • A large fraction of patients with APS-1 and coeliac disease develop enamel dystrophy, characterized by the presence of autoantibodies against the enamel matrix, which are generated through the breakdown of either central (APS-1) or peripheral (coeliac) tolerance to a battery of ameloblast-sepecific proteins.

    • Yael Gruper
    • Anette S. B. Wolff
    • Jakub Abramson
    Research
    Nature
    Volume: 624, P: 653-662

  • The potential recovery of the human gut microbiota after an antibiotic treatment, and its effects on our health, are poorly understood. Here, the authors use a mouse model mimicking paediatric antibiotic use to shed new light into these processes.

    • Yael R. Nobel
    • Laura M. Cox
    • Martin J. Blaser
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15

  • Dysfunction of the deacetylase Sirt1 has been associated with certain metabolic diseases. Abramson and colleagues show that Sirt1 has high expression in the thymus, where it deacetylates the transcriptional regulator Aire and is essential for Aire's ability to switch on the expression of tissue-specific genes.

    • Anna Chuprin
    • Ayelet Avin
    • Jakub Abramson
    Research
    Nature Immunology
    Volume: 16, P: 737-745

  • Abramson and colleagues show that the coordinated action of several transcriptional regulators, including Irf4, Irf8, Tbx21, Tcf7 and Ctcfl, acts on medullary-thymic-epithelial-cell-specific accessible regions in the locus encoding the transcriptional regulator Aire to control its expression.

    • Yonatan Herzig
    • Shir Nevo
    • Jakub Abramson
    Research
    Nature Immunology
    Volume: 18, P: 161-172

  • Recent studies using single-cell genomic technologies and in vivo fate mapping have shown that thymic epithelial cells are far more heterogeneous than previously thought, comprising multiple subpopulations with distinct molecular and functional characteristics.

    • Noam Kadouri
    • Shir Nevo
    • Jakub Abramson
    Reviews
    Nature Reviews Immunology
    Volume: 20, P: 239-253