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Impact of perioperative organ injury on morbidity and mortality in 28 million surgical patients

The impact of perioperative organ injury on surgical outcome is not well understood. Here the authors show the overall impact and the impact of individual perioperative organ injuries in 28 million surgical patients in Germany.

Felix Kork
Yafen Liang
Holger K. Eltzschig
ResearchOpen Access09 Apr 2025
Nature Communications

Volume: 16, P: 1-9
Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice

Calcium/calmodulin-dependent protein kinase IV (CaMK4) has been shown to be involved in autoimmunity but it is not clear how it functions in psoriasis. Here the authors show that CaMK4 is increased in psoriasis and promotes inflammatory responses in mouse models of psoriasis mediated through macrophages and keratinocytes.

Liang Yong
Yafen Yu
Liangdan Sun
ResearchOpen Access22 Jul 2022
Nature Communications

Volume: 13, P: 1-16
BMAL1–HIF2A heterodimer modulates circadian variations of myocardial injury

The core circadian transcription factor BMAL1 regulates circadian-dependent myocardial injury.

Wei Ruan
Tao Li
Holger K. Eltzschig
ResearchOpen Access23 Apr 2025
Nature

Volume: 641, P: 1017-1028
A group of receptor kinases are essential for CLAVATA signalling to maintain stem cell homeostasis

A new family of four receptor kinases in Arabidopsis named CIKs act as co-receptors to integrate all three known CLAVATA3 signalling pathways, to maintain stem cell homeostasis in the shoot apical meristem.

Chong Hu
Yafen Zhu
Xiaoping Gou
Research26 Mar 2018
Nature Plants

Volume: 4, P: 205-211
Interplay of hypoxia-inducible factors and oxygen therapy in cardiovascular medicine

The benefits of oxygen therapy for the treatment of cardiovascular disease are unclear, and findings from preclinical studies have suggested potential adverse effects associated with its excessive use. In this Review, Eltzschig and colleagues provide an overview of studies on oxygen therapy for various cardiovascular conditions and describe alternative therapeutic strategies that target oxygen-sensing pathways.

Yafen Liang
Wei Ruan
Holger K. Eltzschig
Reviews12 Jun 2023
Nature Reviews Cardiology

Volume: 20, P: 723-737

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Impact of perioperative organ injury on morbidity and mortality in 28 million surgical patients

Calcium/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice

BMAL1–HIF2A heterodimer modulates circadian variations of myocardial injury

A group of receptor kinases are essential for CLAVATA signalling to maintain stem cell homeostasis

Interplay of hypoxia-inducible factors and oxygen therapy in cardiovascular medicine

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