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Showing 1–2 of 2 results
Advanced filters: Author: Yagai Yang Clear advanced filters

  • It has been previously shown that combining immune checkpoint inhibitors with TGFβ blockade potentiates anti-tumor immune responses. Here the authors show that, in an immune excluded preclinical tumor model, combining therapeutic anti-PD-L1 with anti-TGFβ treatment promotes expansion and differentiation of stem-cell like CD8 + T cells.

    • Alessandra Castiglioni
    • Yagai Yang
    • Sören Müller
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • In humans, TGFβ signalling is associated with lack of response to immunotherapy in immune-excluded tumours; in mouse models of this immune phenotype, robust tumour infiltration by T cells and tumour regression are observed only when checkpoint inhibition is combined with inhibition of TGFβ signalling.

    • Sanjeev Mariathasan
    • Shannon J. Turley
    • Thomas Powles
    Research
    Nature
    Volume: 554, P: 544-548