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Showing 1–27 of 27 results
Advanced filters: Author: Yamuna Krishnan Clear advanced filters

  • As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?” — here is what they said.

    • Lona M. Alkhalaf
    • Cheryl Arrowsmith
    • Georg Winter
    Special Features
    Nature Chemical Biology
    Volume: 21, P: 6-15

  • Nature Biotechnology asks a selection of researchers about the most exciting frontier in their field and the most needed technologies for advancing knowledge and applications.

    • Ido Amit
    • David Baker
    • Tian Zhang
    Special Features
    Nature Biotechnology
    Volume: 34, P: 270-275

  • DNA nanomachines are synthetic DNA assemblies that switch between defined molecular conformations when stimulated by external triggers. So far, DNA devices have been limited to in vitro applications. A DNA nanomachine has now been constructed that can function as a pH sensor based on fluorescence resonance energy transfer (FRET) inside living cells.

    • Souvik Modi
    • Swetha M. G.
    • Yamuna Krishnan
    Research
    Nature Nanotechnology
    Volume: 4, P: 325-330

  • Precisely engineered DNA nanostructures can be used to deliver small interfering RNA molecules into cells and tumours to suppress genes.

    • Dhiraj Bhatia
    • Saikat Chakraborty
    • Yamuna Krishnan
    News & Views
    Nature Nanotechnology
    Volume: 7, P: 344-346

  • Innate immune cells such as dendritic cells and macrophages can activate the adaptive immune system against cancer by presenting cancer-specific antigens, although this activity is severely limited in macrophages due to their intrinsic lysosomal cysteine protease activity. Here the authors show that a DNA nanodevice specifically targeted to macrophage lysosomes can inhibit cysteine proteases in these cells, restoring their antigen-presenting capability.

    • Chang Cui
    • Kasturi Chakraborty
    • Lev Becker
    Research
    Nature Nanotechnology
    Volume: 16, P: 1394-1402

  • A DNA-based nanosensor that simultaneously measures pH and chloride concentrations can chemically resolve different subpopulations of lysosomes in live cells derived from healthy individuals and patients with Niemann–Pick disease.

    • KaHo Leung
    • Kasturi Chakraborty
    • Yamuna Krishnan
    Research
    Nature Nanotechnology
    Volume: 14, P: 176-183

  • Encapsulating molecules within supramolecular frameworks for potential biological application is challenging. Bhatiaet al. incorporate a fluorescent polymer within an icosahedral DNA nanocapsule, and show that it can be used to target specific cells in vivoand map pH spatially and temporally.

    • Dhiraj Bhatia
    • Sunaina Surana
    • Yamuna Krishnan
    Research
    Nature Communications
    Volume: 2, P: 1-8

  • Many synthetic DNA nanomachines have been developed and demonstratedin vitro, but their use in living organisms has not been reported. Now, a DNA nanomachine, the I-switch, is used to map spatiotemporal pH changes associated with endosomal maturation within coelomocytes of Caenorhabditis elegans.

    • Sunaina Surana
    • Jaffar M. Bhat
    • Yamuna Krishnan
    Research
    Nature Communications
    Volume: 2, P: 1-7

  • To determine the physiologically relevant oligomeric form of membrane proteins is extremely challenging. Now an elegant method of counting the oligomers in membrane proteins in near-native states is presented, using photobleaching and nanodiscs formed directly from cellular membranes.

    • Koushambi Mitra
    • Yamuna Krishnan
    News & Views
    Nature Nanotechnology
    Volume: 19, P: 5-6

  • The DNA-based, ratiometric fluorescent reporter CalipHluor enables quantitative imaging of pH and calcium in acidic organelles with single-organelle resolution. The probe was used to identify a lysosome-specific Ca2+ importer in animals.

    • Nagarjun Narayanaswamy
    • Kasturi Chakraborty
    • Yamuna Krishnan
    Research
    Nature Methods
    Volume: 16, P: 95-102

  • The combination of multiple fluorophores on a hybridized DNA scaffold enables the development of the reporter cHOClate, which is used to simultaneously and quantitatively image hypochlorous acid (HOCl) and pH during phagosome maturation.

    • Shareefa Thekkan
    • Maulik S. Jani
    • Yamuna Krishnan
    Research
    Nature Chemical Biology
    Volume: 15, P: 1165-1172

  • A pair of fluorescent DNA-based probes for nitric oxide reveals that nitric oxide synthase 3 activity in the trans-Golgi network is essential for Golgi structural integrity, despite being tenfold less active there than at the plasma membrane.

    • Maulik S. Jani
    • Junyi Zou
    • Yamuna Krishnan
    Research
    Nature Chemical Biology
    Volume: 16, P: 660-666

  • DNA nanodevice can quantitatively map disulfide reduction exclusively in endosomes in C. elegans, by which the location-specific action of proteins can be addressed.

    • Krishna Dan
    • Aneesh T. Veetil
    • Yamuna Krishnan
    Research
    Nature Nanotechnology
    Volume: 14, P: 252-259

  • Research in nanotechnology in India is on an upswing given the substantial investments in the past two decades. Making an impact globally will now require investing in education, entrepreneurship, translational science, infrastructure for manufacturing, and changing the administrative mindset.

    • Arindam Ghosh
    • Yamuna Krishnan
    Comments & Opinion
    Nature Nanotechnology
    Volume: 9, P: 491-494

  • A DNA-based voltmeter non-invasively measures the membrane potential of organelles.

    • Anand Saminathan
    • John Devany
    • Yamuna Krishnan
    Research
    Nature Nanotechnology
    Volume: 16, P: 96-103

  • A historical perspective on how next-generation sequencing chemistry was developed.

    • Raphaël Rodriguez
    • Yamuna Krishnan
    Reviews
    Nature Biotechnology
    Volume: 41, P: 1709-1715

  • Nucleic acid scaffolds can be precisely interfaced with cellular components, making them interesting materials to probe and program immune cells. In this Perspective, the authors explore nucleic acid technologies for the quantitative detection of single immune cells and for modulating the immune response.

    • Maulik S. Jani
    • Aneesh T. Veetil
    • Yamuna Krishnan
    Reviews
    Nature Reviews Materials
    Volume: 4, P: 451-458

  • This Perspective reviews the molecular, cellular and organismal response pathways that nucleic acid nanodevices are likely to interact with when deployed in living systems, and outlines ways to design nanodevices that either evade or react to the host response.

    • Sunaina Surana
    • Avinash R. Shenoy
    • Yamuna Krishnan
    Reviews
    Nature Nanotechnology
    Volume: 10, P: 741-747

  • Organelles are compartments inside cells that play important parts in intercellular and intracellular communication, reflecting the metabolic state of the cell. This Review discusses biological pathways that can be exploited to target cargo to specific organelles in vivo, highlighting nucleic acids as suitable delivery vehicles for organelle-level imaging, diagnosis and therapy.

    • Anand Saminathan
    • Matthew Zajac
    • Yamuna Krishnan
    Reviews
    Nature Reviews Materials
    Volume: 7, P: 355-371