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Signal Transduction and Targeted Therapy (1)
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Showing 1–4 of 4 results

Advanced filters: Author: Yan-tao Tian Clear advanced filters

Metabolic dysfunction-associated steatotic liver disease accelerates pancreatic cancer progression and metastasis via the macrophage migration inhibitory factor-CD44 axis

Qian Yu
Hui Song
He Ren
ResearchOpen Access16 Jan 2026
Signal Transduction and Targeted Therapy

Volume: 11, P: 1-14
Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening

Feng-cai Zhang
Zhong-ya Sun
Cheng Luo
Research28 Jun 2019
Acta Pharmacologica Sinica

Volume: 41, P: 286-292
VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2

The VHL tumour suppressor gene is lost in approximately 70% of clear cell renal cell carcinoma (ccRCC). In this study, the authors demonstrate that VHL loss in these tumours augments anthracyclines chemotherapy by down-regulation of ALDH2.

Yao-Hui Gao
Zhao-Xia Wu
Li-Shun Wang
ResearchOpen Access15 Jun 2017
Nature Communications

Volume: 8, P: 1-14
Ubiquitin-activating enzyme1 (TgUAE1) acts as a key regulator of Toxoplasma gondii lytic cycle and homeostasis

This study identifies and characterizes TgUAE1 as the canonical E1 ubiquitin-activating enzyme in Toxoplasma gondii, revealing its critical role in parasite fitness and gene regulation, with potential implications for therapeutic development.

Qi-xin Zhou
Dai-qiang Lu
Ya-ni Mou
ResearchOpen Access10 May 2025
Communications Biology

Volume: 8, P: 1-19