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Showing 1–4 of 4 results
Advanced filters: Author: Yange Niu Clear advanced filters

  • SGLT1 is essential for glucose, galactose and water uptake from the intestine, and its inhibitors have broad therapeutic potential. Here, the authors describe the cryo-EM structure of human SGLT1 in complex with an inhibitor.

    • Yange Niu
    • Wenhao Cui
    • Lei Chen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate cholesteryl esters. Here, authors report cryo-EM structures of human SOAT1 which reveal the binding site of the competitive inhibitor CI-976.

    • Chengcheng Guan
    • Yange Niu
    • Lei Chen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11