Nature Search

Targeting hypoxic exosomal IGFBP2 overcomes CD47-mediated immune evasion in glioblastoma

Yanhua Qi
Rongrong Zhao
Hao Xue
ResearchOpen Access31 Jan 2026
Cell Death & Disease

P: 1-13
Intranasal S-2P and lentinan formulation confers broad protection against SARS-CoV-2 VOCs via IFN-γ-dominant mechanisms

Zhendong Pan
Xu Zheng
Ping Zhao
ResearchOpen Access30 Jan 2026
npj Vaccines

P: 1-17
Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis

Ming Qi and colleagues report that compound heterozygous mutations in NMNAT1 cause Leber congenital amaurosis, a childhood form of retinal dystrophy. NMNAT1 encodes an enzyme previously implicated in protection against axonal degeneration.

Pei-Wen Chiang
Juan Wang
Ming Qi
Research29 Jul 2012
Nature Genetics

Volume: 44, P: 972-974
Bioengineered hybrid dual-targeting nanoparticles reprogram the tumour microenvironment for deep glioblastoma photodynamic therapy

The combination of photodynamic therapy and immunotherapy is emerging as a promising treatment for glioblastoma (GBM). Here this group encapsulates Fe3O4@BiFeO3 into bacterial outer membrane vesicles and M1 macrophage-derived exosomes hybrid membrane for synergistic photo-immunotherapy of GBM.

Rongrong Zhao
Ying Hou
Hao Xue
ResearchOpen Access18 Aug 2025
Nature Communications

Volume: 16, P: 1-22
Effect of optical technical of guiding emmetropization lenses on myopia prevention in children without myopia

Qi Zhao
Jiaqi Li
Yanhua Wang
ResearchOpen Access25 Apr 2025
Scientific Reports

Volume: 15, P: 1-6
Differentiation between patent foramen ovale and pulmonary arteriovenous malformations via simultaneous contrast transthoracic echocardiography and transcranial doppler

Jingjin Wang
Zhenhui Zhu
Shiguo Li
ResearchOpen Access17 Dec 2025
Scientific Reports

Volume: 16, P: 1-11
Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking

Volitional reward taking emerges through a sequence of preluding events. Yet, the underlying neural mechanism is not fully understood. Here authors show a series of temporal dynamics of nucleus accumbens neurons that may substantiate such preluding events to commit “free-willed” animals to reward taking.

Terra A. Schall
King-Lun Li
Yan Dong
ResearchOpen Access28 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Inherent asymmetry of Rpd3S coordinates its nucleosome engagement and association with elongating RNA polymerase II

This study reveals the role of the Rpd3S complex in genomic integrity, highlighting how its asymmetrical structure influences interaction with transcribed nucleosomes and elongating RNA polymerase II.

Yixuan Pan
Meiyang Liu
Bing Li
Research08 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 687-697
Metformin protects lens epithelial cells against senescence in a naturally aged mouse model

Mengmeng Chen
Yushan Fu
Yanhua Qi
ResearchOpen Access10 Jan 2022
Cell Death Discovery

Volume: 8, P: 1-9
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer

Small-cell lung cancer (SCLC) is an aggressive disease with limited therapeutic options. Here the authors perform an immunogenomic analysis of limited-stage SCLC, revealing a homogeneous mutational landscape, but limited T-cell infiltration and a cold and heterogeneous T cell repertoire.

Ming Chen
Runzhe Chen
Jianjun Zhang
ResearchOpen Access17 Nov 2021
Nature Communications

Volume: 12, P: 1-13
Identification of a novel missense mutation of MIP in a Chinese family with congenital cataracts by target region capture sequencing

Bo Jiang
Yanhua chen
Liping Shen
ResearchOpen Access06 Jan 2017
Scientific Reports

Volume: 7, P: 1-7
Concerted genomic targeting of H3K27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis

Yuhai Cui and colleagues report that the H3K27 demethylase REF6 targets genomic loci containing a specific DNA motif via its zinc-finger domains. They show that REF6 facilitates the recruitment of BRM and that deleting the DNA motif from a target gene in Arabidopsis makes it inaccessible to REF6.

Chenlong Li
Lianfeng Gu
Yuhai Cui
Research25 Apr 2016
Nature Genetics

Volume: 48, P: 687-693
Rapidly progressive necrotizing enterocolitis: Risk factors and a predictive model

Jicheng Li
Jingjing Zhou
Mingyan Hei
Research15 Aug 2024
Pediatric Research

Volume: 97, P: 1058-1064
MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer

Qian Yang
Shan Kong
Shaoqing Ju
ResearchOpen Access26 Jan 2023
Cell Death & Disease

Volume: 14, P: 1-12
PRL2 negatively regulates FcεRI mediated activation of mast cells

Xin Guo
Yunxuan Lei
Guangjie Chen
ResearchOpen Access21 Apr 2025
Cell Death & Disease

Volume: 16, P: 1-11
Exploration and practice of potential association prediction between diseases and drugs based on Swanson framework and bioinformatics

Yanhua Lv
Yuyang Yuan
Hongxia Zhao
ResearchOpen Access28 Nov 2024
Scientific Reports

Volume: 14, P: 1-15
Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1

Yonggang Zou
Qi Zheng
Hai Song
ResearchOpen Access16 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-13
Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2

Gang Xu
Yezi Wu
Zheng Zhang
ResearchOpen Access07 Sept 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-13
Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia

Qindong Guo
Yang Fan
Gang Li
ResearchOpen Access21 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-14
Tumor-derived exosomes deliver the tumor suppressor miR-3591-3p to induce M2 macrophage polarization and promote glioma progression

Ming Li
Hao Xu
Gang Li
ResearchOpen Access09 Sept 2022
Oncogene

Volume: 41, P: 4618-4632
Hypoxia-induced circADAMTS6 in a TDP43-dependent manner accelerates glioblastoma progression via ANXA2/ NF-κB pathway

Shulin Zhao
Boyan Li
Gang Li
Research17 Nov 2022
Oncogene

Volume: 42, P: 138-153
The dual role of glioma exosomal microRNAs: glioma eliminates tumor suppressor miR-1298-5p via exosomes to promote immunosuppressive effects of MDSCs

Yanhua Qi
Chuandi Jin
Gang Li
ResearchOpen Access02 May 2022
Cell Death & Disease

Volume: 13, P: 1-15
Exosomes derived from hypoxic glioma deliver miR-1246 and miR-10b-5p to normoxic glioma cells to promote migration and invasion

In this study, the authors reveal that the hypoxic microenvironment stimulates glioma to generate miR-1246- and miR-10b-5p-rich exosomes, which are delivered to normoxic glioma cells to promote their migration and invasion by targeting FRK and TFAP2A respectively. Treatment targeting the exosomes and microRNAs may impair the motility of gliomas, providing a novel direction for the development of antitumor therapy.

Mingyu Qian
Zihang Chen
Gang Li
Research14 Jan 2021
Laboratory Investigation

Volume: 101, P: 612-624
Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction

Jianye Xu
Jian Zhang
Gang Li
ResearchOpen Access07 Apr 2021
Cell Death & Disease

Volume: 12, P: 1-16
Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma

Shaobo Wang
Yanhua Qi
Gang Li
ResearchOpen Access03 Mar 2020
Cell Death & Disease

Volume: 11, P: 1-17
Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

Weijia Sun
Chenyang Zhao
Yingxian Li
ResearchOpen Access31 May 2016
Cell Discovery

Volume: 2, P: 1-23
Hepatitis B Virus e Antigen Activates the Suppressor of Cytokine Signaling 2 to Repress Interferon Action

Yi Yu
Pin Wan
Jianguo Wu
ResearchOpen Access11 May 2017
Scientific Reports

Volume: 7, P: 1-15
The role and implication of autophagy in cholangiocarcinoma

Hayat Khizar
Yufei Hu
Jianfeng Yang
ReviewsOpen Access04 Sept 2023
Cell Death Discovery

Volume: 9, P: 1-10

Search

Targeting hypoxic exosomal IGFBP2 overcomes CD47-mediated immune evasion in glioblastoma

Intranasal S-2P and lentinan formulation confers broad protection against SARS-CoV-2 VOCs via IFN-γ-dominant mechanisms

Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis

Bioengineered hybrid dual-targeting nanoparticles reprogram the tumour microenvironment for deep glioblastoma photodynamic therapy

Effect of optical technical of guiding emmetropization lenses on myopia prevention in children without myopia

Differentiation between patent foramen ovale and pulmonary arteriovenous malformations via simultaneous contrast transthoracic echocardiography and transcranial doppler

Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking

Inherent asymmetry of Rpd3S coordinates its nucleosome engagement and association with elongating RNA polymerase II

Metformin protects lens epithelial cells against senescence in a naturally aged mouse model

Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer

Identification of a novel missense mutation of MIP in a Chinese family with congenital cataracts by target region capture sequencing

Concerted genomic targeting of H3K27 demethylase REF6 and chromatin-remodeling ATPase BRM in Arabidopsis

Rapidly progressive necrotizing enterocolitis: Risk factors and a predictive model

MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer

PRL2 negatively regulates FcεRI mediated activation of mast cells

Exploration and practice of potential association prediction between diseases and drugs based on Swanson framework and bioinformatics

Deficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1

Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2

Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia

Tumor-derived exosomes deliver the tumor suppressor miR-3591-3p to induce M2 macrophage polarization and promote glioma progression

Hypoxia-induced circADAMTS6 in a TDP43-dependent manner accelerates glioblastoma progression via ANXA2/ NF-κB pathway

The dual role of glioma exosomal microRNAs: glioma eliminates tumor suppressor miR-1298-5p via exosomes to promote immunosuppressive effects of MDSCs

Exosomes derived from hypoxic glioma deliver miR-1246 and miR-10b-5p to normoxic glioma cells to promote migration and invasion

Hypoxic glioma-derived exosomes promote M2-like macrophage polarization by enhancing autophagy induction

Hypoxia-induced lncRNA PDIA3P1 promotes mesenchymal transition via sponging of miR-124-3p in glioma

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

Hepatitis B Virus e Antigen Activates the Suppressor of Cytokine Signaling 2 to Repress Interferon Action

The role and implication of autophagy in cholangiocarcinoma

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