Kathrin Weber et al. report that the necrosome components RIPK3 and MLKL constitutively shuttle between the nucleus and cytoplasm. They find that increasing ratios of nuclear:cytosolic RIPK3 and MLKL prevents necrotic cell death, suggesting a mechanism by which the cell regulates necrosome formation and death.
- Kathrin Weber
- Ria Roelandt
- Peter Vandenabeele
