Much of the current understanding of oxygen transport at the capillary level comes from mathematical models. Building on earlier work, Alexandre Parpaleix and his colleagues use two-photon phosphorescence lifetime microscopy to show how brain activity can be noninvasively imaged from measurements of oxygen dynamics in capillaries. They demonstrate the presence of an oxygen partial pressure (PO2) initial dip at the level of capillaries and show that tissue PO2 can be inferred from erythrocyte-associated transient values.
- Alexandre Parpaleix
- Yannick Goulam Houssen
- Serge Charpak
