Beclin1 is a key regulator of VPS34-related processes, including autophagy. Liet al. solve the crystal structure of Beclin 1 CC domain, an antiparallel dimer that is rendered metastable by a series of a-d' pairings, which determines its ability to form distinct heterodimers either with Atg14L or UVRAG.
- Xiaohua Li
- Liqiang He
- Yanxiang Zhao
