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Showing 1–3 of 3 results
Advanced filters: Author: Yanzhou Chang Clear advanced filters

  • This study provided a universality method for synthesis of nanotherapeutics for encapsulating various metal complexes. The dual-targeted MP3/AA@NPs greatly improved discrimination between cancer cells and normal cells, moreover, MP3/AA@NPs displayed good in vitro and in vivo antitumor activities as well as stimulating immunotherapeutic response.

    • Jinggong Liu
    • Wenying Li
    • Tianfeng Chen
    ResearchOpen Access
    NPG Asia Materials
    Volume: 15, P: 1-14

  • Ultrathin Bi2Se3-CS-RGD NSs with excellent tumor-targeting ability and potent radiosensitization efficiency are constructed for imaging-guided cancer radiotherapy. The NSs in combination with X-ray irradiation inhibit HeLa cell growth by inducing G0/G1 cycle arrest and mitochondria-mediated intrinsic cell apoptosis, inhibiting TrxR and activating downstream ROS-mediated signaling pathways. Moreover, RGD coating enables the NSs to aggregate in the tumor regions quickly enabling efficient PAI of the entire tumor to facilitate radiotherapy of cervical cancer. Taken together, this study provides an effective and safe theranostic agent for next-generation cancer radiotherapy.

    • Zhenhuan Song
    • Yanzhou Chang
    • Tianfeng Chen
    ResearchOpen Access
    NPG Asia Materials
    Volume: 9, P: e439