Directed cell migration in weak electric fields is known as galvanotaxis, but the cellular sensor and mechanism is not known. Here Nakajima et al. identify inwardly rectifying K+channel Kir4.2 as an important mediator of galvanotaxis, that depends on the cytoplasmic distribution of intracellular polyamines.
- Ken-ichi Nakajima
- Kan Zhu
- Min Zhao