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Midbrain extracellular matrix and microglia are associated with cognition in aging mice

Synapse dysfunction contributes to cognitive decline with age. Here, the authors show that aging-related changes in microglia and the extracellular matrix are associated with synapse abundance, extracellular matrix buildup, and cognitive deficits in aging mice.

Daniel T. Gray
Abigail Gutierrez
Lindsay M. De Biase
ResearchOpen Access27 Nov 2025
Nature Communications

Volume: 16, P: 1-24
Histone H3 lysine 4 methylation recruits DNA demethylases to enforce gene expression in Arabidopsis

This study revealed that targeting H3K4me3 via the H3K4 methyltransferase SDG2 activates gene expression and removes DNA methylation by recruiting DNA demethylases. Conversely, the removal of H3K4me3 synergistically enhances targeted DNA methylation.

Ming Wang
Yan He
Steven E. Jacobsen
ResearchOpen Access11 Feb 2025
Nature Plants

Volume: 11, P: 206-217
A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis

Using a gain-of-function method, this work identified 14 plant proteins that can repress gene expression via diverse epigenetic pathways, including DNA methylation, histone modifications and interference of RNA polymerase II transcription.

Ming Wang
Zhenhui Zhong
Steven E. Jacobsen
ResearchOpen Access06 Mar 2023
Nature Plants

Volume: 9, P: 460-472
Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14

TRB proteins have been shown to recruit PRC2 for H3K27me3 deposition. This work shows that TRBs also recruit JMJ14 to remove H3K4me3, demonstrating that TRBs silence the target genes via a combinatorial histone modification mechanism.

Ming Wang
Zhenhui Zhong
Steven E. Jacobsen
ResearchOpen Access28 Mar 2023
Nature Communications

Volume: 14, P: 1-13
MYCT1 controls environmental sensing in human haematopoietic stem cells

MYCT1 is identified as a crucial regulator of cellular properties essential for the stemness of human haematopoietic stem cells, a finding that may help improve successful in vitro expansion of these cells for therapeutics.

Júlia Aguadé-Gorgorió
Yasaman Jami-Alahmadi
Hanna K. A. Mikkola
ResearchOpen Access05 Jun 2024
Nature

Volume: 630, P: 412-420
Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis

Histone chaperones and chromatin remodelers control nucleosome dynamics. Here the authors show that the Arabidopsis ASF1 chaperone primarily supplies histone variants to the HIRA complex to ensure proper epigenetic gene regulation.

Zhenhui Zhong
Yafei Wang
Steven E. Jacobsen
ResearchOpen Access15 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Crym-positive striatal astrocytes gate perseverative behaviour

In mice, a population of astrocytes in the central striatum, characterized by expression of μ-crystallin, has a role in perseveration phenotypes that are often associated with human neuropsychiatric disorders.

Matthias Ollivier
Joselyn S. Soto
Baljit S. Khakh
ResearchOpen Access28 Feb 2024
Nature

Volume: 627, P: 358-366
Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation

MORC ATPases are required for transposable element silencing and heterochromatin condensation in plants and animals. Here the authors show that Arabidopsis MORCs colocalize with sites of RNA-directed DNA methylation and provide evidence that they act as molecular tethers to efficiently establish DNA methylation.

Yan Xue
Zhenhui Zhong
Steven E. Jacobsen
ResearchOpen Access13 Jul 2021
Nature Communications

Volume: 12, P: 1-13
Astrocyte–neuron subproteomes and obsessive–compulsive disorder mechanisms

Analyses of the proteomes of astrocytes and neurons in a cell-specific and subcompartment-specific manner reveal distinct roles for these cell types that are relevant to obsessive–compulsive disorder and perhaps other brain disorders.

Joselyn S. Soto
Yasaman Jami-Alahmadi
Baljit S. Khakh
ResearchOpen Access12 Apr 2023
Nature

Volume: 616, P: 764-773
The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation

It has generally been considered that MOM1, a transcriptional silencing factor in plants, mediated silencing is independent or downstream of DNA methylation. Here, the authors show that MOM1 complex recruits the RdDM machinery through MORC6 to establish de novo DNA methylation in Arabidopsis.

Zheng Li
Ming Wang
Steven E. Jacobsen
ResearchOpen Access12 Jul 2023
Nature Communications

Volume: 14, P: 1-16
CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization

An adipocyte-selective product of the Clstn3 locus (CLSTN3β) facilitates the use of stored triglyceride by limiting lipid droplet (LD) expansion, defining a molecular mechanism that regulates LD form and function to facilitate lipid utilization in thermogenic adipocytes.

Kevin Qian
Marcus J. Tol
Peter Tontonoz
Research07 Dec 2022
Nature

Volume: 613, P: 160-168
In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation

A protocol detailing the labeling and identification of cell- and subcompartment-specific proteins found within intact astrocytes and neurons in vivo using the proximity-dependent biotinylation system BioID2.

Joselyn S. Soto
Yasaman Jami-Alahmadi
Baljit S. Khakh
Protocols07 Dec 2023
Nature Protocols

Volume: 19, P: 896-927
Comprehensive identification of SWI/SNF complex subunits underpins deep eukaryotic ancestry and reveals new plant components

The ancestral history of SWI/SNF subunits, responsible for nucleosome positioning, are explored in this work, revealing a plant SWI/SNF complex similar to the animal BAF subclass.

Jorge Hernández-García
Borja Diego-Martin
Javier Gallego-Bartolomé
ResearchOpen Access06 Jun 2022
Communications Biology

Volume: 5, P: 1-11
Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway

Gabriele Colozza
Yasaman Jami-Alahmadi
Edward M. De Robertis
ResearchOpen Access09 Dec 2020
Scientific Reports

Volume: 10, P: 1-14

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Midbrain extracellular matrix and microglia are associated with cognition in aging mice

Histone H3 lysine 4 methylation recruits DNA demethylases to enforce gene expression in Arabidopsis

A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis

Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14

MYCT1 controls environmental sensing in human haematopoietic stem cells

Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis

Crym-positive striatal astrocytes gate perseverative behaviour

Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation

Astrocyte–neuron subproteomes and obsessive–compulsive disorder mechanisms

The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation

CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization

In vivo identification of astrocyte and neuron subproteomes by proximity-dependent biotinylation

Comprehensive identification of SWI/SNF complex subunits underpins deep eukaryotic ancestry and reveals new plant components

Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway

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