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Showing 1–4 of 4 results
Advanced filters: Author: Yasin Pourfarjam Clear advanced filters

  • Tri-complex inhibitors—molecular glues with the ability to recruit cyclophilin A to the active state of RAS—stimulate GTP hydrolysis in a mutant-specific manner. 

    • Antonio Cuevas-Navarro
    • Yasin Pourfarjam
    • Piro Lito
    ResearchOpen Access
    Nature
    Volume: 637, P: 224-229

  • A non-covalent inhibitor that binds preferentially to the inactive state of KRAS while sparing NRAS and HRAS is reported, indicating that most KRAS oncoproteins cycle between an active state and an inactive state in cancer cells.

    • Dongsung Kim
    • Lorenz Herdeis
    • Piro Lito
    ResearchOpen Access
    Nature
    Volume: 619, P: 160-166

  • PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG inhibition sensitizes cells to ionizing radiation and kills cancer cells through replication fork defects.

    • Jerry H. Houl
    • Zu Ye
    • John A. Tainer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15