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Showing 1–4 of 4 results
Advanced filters: Author: Yasmina Cuartero Clear advanced filters

  • Ewing sarcoma (ES) is characterized by EWSR1/ETS gene rearrangements with unknown cellular origin. Here, authors show that expressing the EWS::FLI1 oncogene in human embryonic mesenchymal stem cells induces an Ewing sarcoma-like transcriptome and forms tumors in mice.

    • Inmaculada Hernández-Muñoz
    • Irene Cuervas
    • Jaume Mora
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • How mammalian genomes are packaged and the heritability of structural variations in genome folding is incomplete. Here, the authors investigate the impact of chromosomal fusions on three-dimensional genome topology and meiotic recombination, highlighting the implications of large-scale genome reorganizations on genome function, evolution, and fertility.

    • Covadonga Vara
    • Andreu Paytuví-Gallart
    • Aurora Ruiz-Herrera
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Lamina-associated domains (LADs) contact lamins in the nuclear lamina, and lamin B1 was thought to bind heterochromatic regions at the nuclear envelope. Here, the authors show lamin B1 associates with actively expressed euchromatin regions, creating dynamic euchromatin lamina-associated domains (eLADs) during epithelial-to-mesenchymal transition.

    • Laura Pascual-Reguant
    • Enrique Blanco
    • Sandra Peiró
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • The authors analyze time-resolved changes in genome topology, gene expression, transcription-factor binding, and chromatin state during iPSC generation. They conclude that 3D genome reorganization generally precedes gene expression changes and that removal of locus-specific topological barriers explains why pluripotency genes are activated sequentially during reprogramming.

    • Ralph Stadhouders
    • Enrique Vidal
    • Thomas Graf
    Research
    Nature Genetics
    Volume: 50, P: 238-249