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Showing 1–8 of 8 results
Advanced filters: Author: Yassene Mohammed Clear advanced filters

  • The authors introduce the Neurolipid Atlas, a dynamic resource for the community to gain insight into lipid alterations in neurodegenerative disease, and they leverage the platform to show how cholesterol alterations in astrocytes can dysregulate neuroinflammatory pathways in Alzheimer disease.

    • Femke M. Feringa
    • Sascha J. Koppes-den Hertog
    • Rik van der Kant
    ResearchOpen Access
    Nature Metabolism
    Volume: 7, P: 2142-2164

  • Lipidomics revealed that neurons of patients with ALS/FTD have reduced levels of polyunsaturated fatty acid (PUFA)-containing phospholipids. Increasing neuronal PUFA levels increased survival of Drosophila models of ALS/FTD and patient neurons, suggesting that interventions that increase neuronal PUFA levels in patients with ALS/FTD may also be beneficial.

    • Ashling Giblin
    • Alexander J. Cammack
    • Adrian M. Isaacs
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 737-747

  • Cellular functional states are supported by metabolic pathways, including lipid metabolism. Here, authors examine the contribution of differential biosynthesis of lipid mediators to innate immune memory (or trained immunity), in human monocytes following Bacillus Calmette-Guérin (BCG) vaccination.

    • Anaísa V. Ferreira
    • Juan Carlos Alarcon-Barrera
    • Martin Giera
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • In this Resource, the authors present FedProt, a tool that enables privacy-preserving, federated differential protein abundance analysis across multiple institutions. Its results match the results of centralized analysis, enabling secure, collaborative proteomics without sensitive data sharing.

    • Yuliya Burankova
    • Miriam Abele
    • Olga Zolotareva
    ResearchOpen Access
    Nature Computational Science
    Volume: 5, P: 675-688

  • Christoph Borchers, Albert Sickmann and colleagues present multiple reaction monitoring/mass spectrometry assays for reproducible quantification of 500 plasma proteins in mice. They report reference protein concentrations in five mouse strains, and inter- and intra-strain phenotypic variations.

    • Sarah A. Michaud
    • Nicholas J. Sinclair
    • Christoph H. Borchers
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-9