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Showing 1–7 of 7 results
Advanced filters: Author: Yasuhide Takeuchi Clear advanced filters

  • In patients with ulcerative colitis, chronic inflammation can lead to remodelling of the colorectal epithelium through positive selection of clones with mutations in genes related to IL-17 signalling, which, however, might be negatively selected during colitis-associated carcinogenesis.

    • Nobuyuki Kakiuchi
    • Kenichi Yoshida
    • Seishi Ogawa
    Research
    Nature
    Volume: 577, P: 260-265

  • By using phylogenetic analyses of multiple microdissected samples from both cancer and non-cancer lesions, unique evolutionary histories of breast cancers harbouring a common driver alteration are shown, providing new insight into how breast cancer evolves.

    • Tomomi Nishimura
    • Nobuyuki Kakiuchi
    • Seishi Ogawa
    ResearchOpen Access
    Nature
    Volume: 620, P: 607-614

  • A20 is a negative regulator of the NF-κB pathway and has a pivotal role in regulation of the immune response. Using a genome-wide analysis of genetic lesions in B-cell lymphomas, A20 is shown to be a common genetic target in B-lineage lymphomas, with uncontrolled NF-κB signalling caused by loss of A20 function implicated in the pathogenesis of subsets of these lymphomas.

    • Motohiro Kato
    • Masashi Sanada
    • Seishi Ogawa
    Research
    Nature
    Volume: 459, P: 712-716

  • In physiologically normal epithelia, age-related expansion of clones that carry mutations in NOTCH1 and other driver genes is accelerated by risk factors for developing oesophageal squamous cell carcinoma, such as alcohol consumption or smoking.

    • Akira Yokoyama
    • Nobuyuki Kakiuchi
    • Seishi Ogawa
    Research
    Nature
    Volume: 565, P: 312-317

  • Endoplasmic reticulum (ER) stress has been proposed to play a role in metabolic diseases. Here, Sasako and colleagues identify stromal cell-derived factor 2 like 1 (Sdf2l1) as a regulator of the ER stress response to feeding in the liver, and suggest that its downregulation may promote diabetes and hepatic steatosis in humans.

    • Takayoshi Sasako
    • Mitsuru Ohsugi
    • Kohjiro Ueki
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Yukiko Inagaki-Kawata et al. report an analysis of germline variants in breast cancer susceptibility genes in 1,995 Japanese breast cancer patients. They find that 5.1% of the patients carry germline variants in cancer-linked genes and investigate the characteristics of patients with germline mutations in BRCA1/2.

    • Yukiko Inagaki-Kawata
    • Kenichi Yoshida
    • Masakazu Toi
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-9