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Showing 1–2 of 2 results
Advanced filters: Author: Yasuki Ishizaki Clear advanced filters

  • This study shows that TRPC5 is an important negative regulator of retinal ganglion cell (RGC) axonal outgrowth and an important regulator of neurite remodeling. The authors hypothesize that TRPC5 senses abnormal intraocular pressure changes and contributes to the death of RGCs in disease. In glaucoma, for example, excessive Ca2+ entry through TRPC5 might induce dendritic and axonal remodeling, which could lead to cell death.

    • Mai Oda
    • Hanako Yamamoto
    • Koji Shibasaki
    Research
    Laboratory Investigation
    Volume: 100, P: 297-310

  • The authors reveal that TRPV4, a thermosensitive ion channel, is constitutively active in the brain. They found that local brain temperature is increased at epileptogenic foci, and that hyperthermia lead TRPV4 over-activation and hyper-neuronal activities. Notably, brain cooling treatment drastically suppresses epileptic discharges dependent on the inactivation of TRPV4.

    • Koji Shibasaki
    • Katsuya Yamada
    • Yasuki Ishizaki
    Research
    Laboratory Investigation
    Volume: 100, P: 274-284