Nature Search

Cilostazol's Effect on the Response to Perivascular Nerve Stimulation in Isolated Dog Cerebral and Mesenteric Arteries

Kazuhide Ayajiki
Yasushi Ozeki
Tomio Okamura
Research01 Jul 2008
Hypertension Research

Volume: 31, P: 1425-1433
The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase

Membrane potentials in living cells can function as electrical signals. Here, the authors report that spermatozoa utilize their electrical signals during the maturing stage to create appropriate membrane lipids environment that is important for sperm motility.

Takafumi Kawai
Shin Morioka
Yasushi Okamura
ResearchOpen Access24 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning

Tatsuya Yoshizawa
Yuki Handa
Shigeaki Kato
Research01 Aug 1997
Nature Genetics

Volume: 16, P: 391-396
Genotypes of aldehyde dehydrogenase and alcohol dehydrogenase polymorphisms in patients with leber’s hereditary optic neuropathy

Yasushi Isashiki
Yoshiaki Tabata
Norio Ohba
Research01 Mar 1997
Japanese Journal of Human Genetics

Volume: 42, P: 187-191
X-ray crystal structure of voltage-gated proton channel

Structural and functional analysis reveal the resting state of the voltage-gated proton channel Hv1. Comparison with structures of voltage-sensing domains from other systems, captured in the activated state, will aid in understanding the mechanism of voltage sensing.

Kohei Takeshita
Souhei Sakata
Atsushi Nakagawa
Research02 Mar 2014
Nature Structural & Molecular Biology

Volume: 21, P: 352-357
Phosphoinositide phosphatase activity coupled to an intrinsic voltage sensor

Yoshimichi Murata
Hirohide Iwasaki
Yasushi Okamura
Research18 May 2005
Nature

Volume: 435, P: 1239-1243
Impact of ERCC1 on the outcomes of chemotherapy in advanced biliary tract cancer

Yasunari Sakamoto
Chigusa Morizane
Junji Furuse
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-11
Clinical effects of recombinant thrombomodulin and defibrotide on sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation

Kimikazu Yakushijin
Takayuki Ikezoe
Takahiro Fukuda
Research20 Aug 2018
Bone Marrow Transplantation

Volume: 54, P: 674-680
Improving membrane voltage measurements using FRET with new fluorescent proteins

Designing fluorescent protein-based sensors that display large changes in fluorescence resonance energy transfer (FRET) is challenging. Redesign of a FRET-based voltage sensor using new fluorescent proteins increased the sensor response to changes in membrane voltage and measurements at warmer temperatures displayed faster kinetics comparable to action potentials.

Hidekazu Tsutsui
Satoshi Karasawa
Atsushi Miyawaki
Research11 Jul 2008
Nature Methods

Volume: 5, P: 683-685
PI couples voltage to catalysis

Functionally coupled motions between the voltage-sensing and the phosphatidylinositol phosphatase domains of the sea squirt protein Ci-VSP is mediated by PI(4,5)P₂ binding to the intervening linker, shedding light on the function of an unusual voltage-sensing protein.

Yasushi Okamura
News & Views01 May 2010
Nature Chemical Biology

Volume: 6, P: 315-316
Influence of ultrasound transmit frequency on measurement of global longitudinal strain on 2D speckle tracking echocardiography

Katsuomi Iwakura
Toshinari Onishi
Atsunori Okamura
ResearchOpen Access14 Dec 2023
Scientific Reports

Volume: 13, P: 1-9
Anionic Polymerizations of 1-(2-Methoxyphenyl)-1,3-butadiene and 1-(4-Methoxyphenyl)-1,3-butadiene—Microstructures of Polymers and Characterizations of Living Anion Chain Ends—

Yasushi Tsuji
Toshimitsu Suzuki
Yoshinobu Takegami
Research01 Jul 1981
Polymer Journal

Volume: 13, P: 651-656
Low-dose anti-thymocyte globulin for GVHD prophylaxis in HLA-matched allogeneic peripheral blood stem cell transplantation

Souichi Shiratori
Junichi Sugita
Mine Harada
Research05 Jul 2020
Bone Marrow Transplantation

Volume: 56, P: 129-136
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
The cytoplasmic coiled-coil mediates cooperative gating temperature sensitivity in the voltage-gated H⁺ channel Hv1

In the dimeric voltage-gated H⁺channel, Hv1/VSOP, the gating of each subunit is coupled, but the molecular basis of dimer formation and intersubunit coupling is unclear. This study shows that channel assembly and cooperative gating are mediated by the cytoplasmic domain.

Yuichiro Fujiwara
Tatsuki Kurokawa
Yasushi Okamura
ResearchOpen Access08 May 2012
Nature Communications

Volume: 3, P: 1-11
Salt-sensitive hypertension in circadian clock–deficient Cry-null mice involves dysregulated adrenal Hsd3b6

The circadian clock controls many aspects of human physiology, and disturbances in circadian rhythms have been linked to cardiovascular disease. Masao Doi et al. now delineate a new pathway by which the circadian clock influences hormone production and blood pressure in mice—clock genes control expression of an aldosterone biosynthetic enzyme, such that increased activity of this enzyme in mice with a disrupted circadian clock may account for the increased aldosterone levels and salt-sensitive hypertension seen in these mice.

Masao Doi
Yukari Takahashi
Hitoshi Okamura
Research13 Dec 2009
Nature Medicine

Volume: 16, P: 67-74
Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells

The mechanisms that trigger meiosis in germ cells and halt this process in non-germline cells are unclear. Here, the authors show that knockout of Maxin embryonic stem cells results in meiotic onset in a mechanism that involves the PRC1 complex.

Ayumu Suzuki
Masataka Hirasaki
Akihiko Okuda
ResearchOpen Access30 Mar 2016
Nature Communications

Volume: 7, P: 1-15
The WATCH-DM risk score estimates clinical outcomes in type 2 diabetic patients with heart failure with preserved ejection fraction

Katsuomi Iwakura
Toshinari Onishi
Hiroya Mizuno
ResearchOpen Access19 Jan 2024
Scientific Reports

Volume: 14, P: 1-12
Impact of Metabolic Syndrome Components on the Incidence of Cardiovascular Disease in a General Urban Japanese Population: The Suita Study

Yoshihiro Kokubo
Tomonori Okamura
Hitonobu Tomoike
Research01 Nov 2008
Hypertension Research

Volume: 31, P: 2027-2035
Prevalence of unilateral hyperaldosteronism in primary aldosteronism: impact of a novel chemiluminescent immunoassay for measuring plasma aldosterone in Japan

Hiroki Kobayashi
Yoshihiro Nakamura
Michio Otsuki
Research29 Jul 2024
Hypertension Research

Volume: 47, P: 3035-3044
Catheter-based ultrasound renal denervation in patients with resistant hypertension: the randomized, controlled REQUIRE trial

Kazuomi Kario
Yoshiaki Yokoi
Shinsuke Nanto
ResearchOpen Access15 Oct 2021
Hypertension Research

Volume: 45, P: 221-231
Energy-efficient production of vaccine protein against porcine edema disease from transgenic lettuce (Lactuca sativa L.)

Asuka Yokoyama
Seika Oiwa
Takeshi Matsumura
ResearchOpen Access24 Sept 2022
Scientific Reports

Volume: 12, P: 1-11
The clinical outcomes of combination chemotherapy in elderly patients with advanced biliary tract cancer: an exploratory analysis of JCOG1113

Ikuhiro Yamada
Chigusa Morizane
Junji Furuse
ResearchOpen Access19 Jan 2022
Scientific Reports

Volume: 12, P: 1-9
Diverse pathological lesions of primary aldosteronism and their clinical significance

Koshiro Nishimoto
Hironobu Umakoshi
Chiba Yoshiro
ResearchOpen Access12 Jan 2021
Hypertension Research

Volume: 44, P: 498-507
(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice

Rei Yokoyama
Yukio Ago
Hitoshi Hashimoto
ResearchOpen Access23 Feb 2024
Molecular Psychiatry

Volume: 29, P: 1406-1416
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Nonlinear excitation of energetic particle driven geodesic acoustic mode by resonance overlap with Alfvén instability in ASDEX Upgrade

Hao Wang
Philipp Lauber
S. Zoletnik
ResearchOpen Access07 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Critical contributions of pre-S1 shoulder and distal TRP box in DAG-activated TRPC6 channel by PIP₂ regulation

Masayuki X. Mori
Ryo Okada
Ryuji Inoue
ResearchOpen Access24 Jun 2022
Scientific Reports

Volume: 12, P: 1-13
Voltage-sensing phosphatase (Vsp) regulates endocytosis-dependent nutrient absorption in chordate enterocytes

The physiological role of Vsp in zebrafish is assessed, revealing Vsp expression in the mid-intestine for dietary protein absorption. A comparative study on marine invertebrate Ciona intestinalis suggests conservation of Vsp function in the GI tract.

Adisorn Ratanayotha
Makoto Matsuda
Yasushi Okamura
ResearchOpen Access10 Sept 2022
Communications Biology

Volume: 5, P: 1-15
Association of cardiovascular disease risk and changes in renin levels by mineralocorticoid receptor antagonists in patients with primary aldosteronism

Regarding Japanese primary aldosteronism, the low, intermediate, and high renin change groups (classified based on the response of renin to mineralocorticoid antagonist treatment) had CVD incidence of 2.1%, 0.5%, and 3.7%, respectively, during the 5-year study period.

Motoko Nomura
Isao Kurihara
Chiba Yoshiro
Research28 Jun 2022
Hypertension Research

Volume: 45, P: 1476-1485
PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes

Salman Mahmud Siddique
Koji Kubouchi
Hideyuki Mukai
ResearchOpen Access27 Sept 2019
Scientific Reports

Volume: 9, P: 1-14
Structural basis for the membrane association of ankyrinG via palmitoylation

Yuichiro Fujiwara
Hiroko X. Kondo
Kengo Kinoshita
ResearchOpen Access05 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Genetically encoded bioluminescent voltage indicator for multi-purpose use in wide range of bioimaging

Shigenori Inagaki
Hidekazu Tsutsui
Takeharu Nagai
ResearchOpen Access13 Feb 2017
Scientific Reports

Volume: 7, P: 1-11
Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?

Hemmings Wu
Marwan Hariz
Bart Nuttin
ReviewsOpen Access03 Nov 2020
Molecular Psychiatry

Volume: 26, P: 60-65
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
High sensitivity of asymmetric ¹⁸F-THK5351 PET abnormality in patients with corticobasal syndrome

Masanori Kurihara
Kenji Ishibashi
Atsushi Iwata
ResearchOpen Access27 Jul 2023
Scientific Reports

Volume: 13, P: 1-9
Dynamic nanoimaging of extended objects via hard X-ray multiple-shot coherent diffraction with projection illumination optics

Coherent diffraction imaging (CDI) is a lensless technique for 2D or 3D reconstruction of nanoscale structure images, where a highly coherent beam of x-rays, electrons or other wavelike particle or photon is incident on an object. The authors present a phase retrieval algorithm that takes advantage of the continuity of physical phenomena and uses it as a temporal constraint for CDI, and also present an illumination optics suitable for the method, which allow them to follow dynamic processes, as demonstrate in their proof-of-principle experiment.

Yuki Takayama
Keizo Fukuda
Yasushi Kagoshima
ResearchOpen Access11 Mar 2021
Communications Physics

Volume: 4, P: 1-16
PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes

Hiroyuki Yano
Mashito Sakai
Michihiro Matsumoto
ResearchOpen Access24 Sept 2018
Scientific Reports

Volume: 8, P: 1-16

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