Coordinated hormonal interactions in response to feeding and fasting regulate glucose homeostasis. Here the authors report that Activin B, expressed in the liver sinusoidal endothelial cells, is involved in glucose homeostasis by regulating hepatic FGF21 production and glucagon sensitivity and can be inhibited by adipocyte-derived FSTL3 during obesity.
- Naoki Kobayashi
- Yukiko Okazaki
- Kohjiro Ueki
