Nature Search

Bioengineered ferritin-based lysosome-targeting chimera platform for tumor-targeted therapy

Lysosome-targeting chimeras (LYTACs) hold therapeutic potential by degrading pathogenesis associated proteins, but current LYTAC systems often require case-by-case constructions and are devoid of a convenient and efficient modular platform. Here, the authors address these issues by developing a modular ferritin-based LYTAC platform for targeted degradation of membrane proteins for cancer therapy.

Shuai Zhang
Yiliang Jin
Kelong Fan
ResearchOpen Access09 Mar 2026
Nature Communications

P: 1-16
Single cell sequencing reveals that CD39 inhibition mediates changes to the tumor microenvironment

The molecular mechanisms underlying tumour heterogeneity in bladder cancer remain to be explored. Here, the authors perform single cell RNA sequencing and identify CD39 as a potential target for immunotherapy, which they validate in vivo.

Lilong Liu
Yaxin Hou
Ke Chen
ResearchOpen Access08 Nov 2022
Nature Communications

Volume: 13, P: 1-16
Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression

Multi-omic analysis of 100 clear cell renal cell carcinomas identifies four transcriptomic subgroups (IM1–IM4). IM4 is a high-risk subtype characterized by specific metabolic changes and a loss of lipid droplets.

Junyi Hu
Shao-Gang Wang
Ke Chen
ResearchOpen Access15 Feb 2024
Nature Genetics

Volume: 56, P: 442-457
Spatially resolved transcriptomic analysis of the adult human prostate

Multi-omic analysis of the adult human prostate identifies spatially resolved cell populations with potential links to prostate carcinogenesis.

Junyi Hu
Fei Liu
Shancheng Ren
Research01 Apr 2025
Nature Genetics

Volume: 57, P: 922-933
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

A small-molecule aldolase inhibitor, aldolazin is reported and shown to selectively activate the lysosomal pool of AMPK, which has glucose-lowering effects in rodents.

Chen-Song Zhang
Mengqi Li
Sheng-Cai Lin
ResearchOpen Access10 Oct 2022
Nature Metabolism

Volume: 4, P: 1369-1401
A deep learning system for detecting diabetic retinopathy across the disease spectrum

As the leading cause of vision loss in working-age adults, diabetic retinopathy requires routinely retinal screening. Here the authors develop a deep learning system that can facilitate the screening by providing real-time image quality assessment, lesions detection, and grades across the disease spectrum.

Ling Dai
Liang Wu
Weiping Jia
ResearchOpen Access28 May 2021
Nature Communications

Volume: 12, P: 1-11
Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma

Bladder urothelial carcinoma is one of the most prevalent urogenital cancer types with limited therapeutic options. Here, the authors characterize the tumor immune microenvironment of bladder cancer using single cell RNA sequencing and suggest a role for inflammatory cancer-associated fibroblasts in tumor progression.

Zhaohui Chen
Lijie Zhou
Ke Chen
ResearchOpen Access08 Oct 2020
Nature Communications

Volume: 11, P: 1-12
Graphene-supported Pd catalyst for highly selective hydrogenation of resorcinol to 1, 3-cyclohexanedione through giant π-conjugate interactions

Zuojun Wei
Ruofei Pan
Yingxin Liu
ResearchOpen Access23 Oct 2015
Scientific Reports

Volume: 5, P: 1-9
Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations

Yaxin Hou
Guoheng Tang
Kelong Fan
ResearchOpen Access08 Jul 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-15

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