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Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms

During cell division, chromosome alignment is engendered by connection of microtubules to kinetochores, coordinated by Aurora B and PLK1. Here, the authors show that the RSF1-PLK1 axis creates an activating phosphorylation on T236 in the GT motif of Aurora B and this is indispensable for Aurora B activation.

Ho-Soo Lee
Sunwoo Min
Hyeseong Cho
ResearchOpen Access11 Oct 2021
Nature Communications

Volume: 12, P: 1-14
Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

How NMDAR and GABA neuronal dysfunctions result in impaired social behaviour is unclear. Here, the authors show that NMDARs and gap junctions in cortical PV interneurons modulate burst firing, affecting social behaviour.

Eunee Lee
Seungjoon Lee
Eunjoon Kim
ResearchOpen Access25 Aug 2021
Nature Communications

Volume: 12, P: 1-20
Butyrate potentiates Enterococcus faecalis lipoteichoic acid-induced inflammasome activation via histone deacetylase inhibition

Ok-Jin Park
Ye-Eun Ha
Seung Hyun Han
ResearchOpen Access28 Mar 2023
Cell Death Discovery

Volume: 9, P: 1-10

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