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Showing 1–8 of 8 results
Advanced filters: Author: Yehudi Bloch Clear advanced filters

  • Structures of complete extracellular receptor assemblies mediated by the pro-inflammatory cytokines IL-12 and IL-23 reveal key commonalities and diverse features, with only IL-12 juxtaposing receptor domains proximal to the cell membrane.

    • Yehudi Bloch
    • Jan Felix
    • Savvas N. Savvides
    Research
    Nature Structural & Molecular Biology
    Volume: 31, P: 591-597

  • Structural studies of the complex of anaplastic lymphoma kinase and leukocyte tyrosine kinase and their activating cytokines identify unique architectural features of the complex, and provide a novel mechanistic paradigm among receptor tyrosine kinases.

    • Steven De Munck
    • Mathias Provost
    • Savvas N. Savvides
    Research
    Nature
    Volume: 600, P: 143-147

  • AtEH/Pan1 proteins contain two N-terminal Eps15 homology (EH) domains and are subunits of the endocytic TPLATE complex present in plants. Here, the authors combine X-ray crystallography, NMR and MD simulations with biochemical and in planta analysis to characterize the two AtEH1/Pan1 EH domains and reveal their structural differences and complementary functional roles.

    • Klaas Yperman
    • Anna C. Papageorgiou
    • Daniel Van Damme
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Protein scaffolds can serve as alternatives to antibodies in a range of applications. Here, the authors report the design and development of Alphabody™, a protein scaffold featuring a single-chain antiparallel triple-helix coiled-coil fold that the authors use to develop Alphabodies that can neutralize human IL-23 with high specificity and affinity.

    • Johan Desmet
    • Kenneth Verstraete
    • Savvas N. Savvides
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-12

  • Viruses often subvert the host immune system using molecular decoys to prevent an effective immune response. Here, the authors examine the structural details of the viral decoy receptor GIF and its antagnosim of GM-CSF and IL-2.

    • Jan Felix
    • Eaazhisai Kandiah
    • Savvas N. Savvides
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Invariant natural killer T (iNKT) cells rapidly enhance cytokine secretion and effector function following activation, but the underlying mechanism is still unclear. Here the authors show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1α, activates the p38 kinase to stabilize cytokine mRNA for enhanced iNKT functions.

    • Srinath Govindarajan
    • Djoere Gaublomme
    • Michael B. Drennan
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Thymic stromal lymphopoietin (TSLP) is a cytokine critical for the development of chronic inflammatory disorders including asthma and atopic dermatitis. The structure of the ternary complex formed by TSLP and its coreceptors TSLPR and the interleukin-7 receptor reveal how TSLP is able to organize receptor-receptor contacts to facilitate intracellular signaling.

    • Kenneth Verstraete
    • Loes van Schie
    • Savvas N Savvides
    Research
    Nature Structural & Molecular Biology
    Volume: 21, P: 375-382