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Showing 1–4 of 4 results
Advanced filters: Author: Yelena Koldobskaya Clear advanced filters

  • Functional studies of O-GlcNAcylation have often focused on individual modifications. Now, a systems-level approach has identified simultaneous O-GlcNAcylation events that coordinate cellular activities and tissue-specific functions.

    • Matthew E. Griffin
    • John W. Thompson
    • Linda C. Hsieh-Wilson
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-12

  • Picornaviruses use modular RNA domains in their internal ribosome entry sites (IRESs) for translation through non-canonical, cap-independent mechanisms. Here the authors report the crystal structure of domain V from the IRES of hepatitis A virus (HAV) ssRNA genome, suggesting that the functional homology among different types of picornaviral IRESs is structure-based.

    • Deepak Koirala
    • Yaming Shao
    • Joseph A. Piccirilli
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Spinach is an RNA aptamer analog of GFP that is widely used for fluorescent labeling of cellular RNAs. Crystal structures of Spinach–fluorophore complexes uncover an unusual G-quadruplex RNA fold that is involved in ligand recognition and tuning of Spinach fluorescence properties.

    • Hao Huang
    • Nikolai B Suslov
    • Joseph A Piccirilli
    Research
    Nature Chemical Biology
    Volume: 10, P: 686-691

  • Crystallization of RNA molecules can pose a challenge, and the U1A RNA binding protein has been used to facilitate the process. Now a different portable RNA sequence and a synthetic Fab are presented as tools for RNA structural determination. In addition to functioning as a crystallization chaperone, the Fab also serves as the search model to provide phase information.

    • Yelena Koldobskaya
    • Erica M Duguid
    • Joseph A Piccirilli
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 100-106