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Advanced filters: Author: Yen-Der Li Clear advanced filters

Template-assisted covalent modification underlies activity of covalent molecular glues

Characterization of DCAF16-based BRD4 molecular glue degraders revealed a trans-labeling mechanism termed ‘template-assisted covalent modification’, which opens a new path for proximity-driven pharmacology.

Yen-Der Li
Michelle W. Ma
Benjamin L. Ebert
ResearchOpen Access29 Jul 2024
Nature Chemical Biology

Volume: 20, P: 1640-1649
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

The cyclin-dependent kinase inhibitor CR8 acts as a molecular glue compound by inducing the formation of a complex between CDK12–cyclin K and DDB1, which results in the ubiquitination and degradation of cyclin K.

Mikołaj Słabicki
Zuzanna Kozicka
Benjamin L. Ebert
Research03 Jun 2020
Nature

Volume: 585, P: 293-297

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Template-assisted covalent modification underlies activity of covalent molecular glues

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

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