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Showing 1–5 of 5 results
Advanced filters: Author: Yeonkyoung Park Clear advanced filters

  • Misfolded polypeptide aggregates are actively transported to aggresomes, where they are degraded through aggrephagy. Here the authors show that these aggregates are selectively recognized by the CTIF–eEF1A1–DCTN1 (CED) complex and transported to aggresomes through the interactions of DCTN1 with dynein motors.

    • Joori Park
    • Yeonkyoung Park
    • Yoon Ki Kim
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Nonsense-mediated mRNA decay (NMD) is a translation-coupled process that eliminates mRNAs containing premature translation-termination codons. Here the authors identify a role for the NMD factor UPF1 in protein quality control, whereby truncated misfolded polypeptides are cleared through autophagy.

    • Yeonkyoung Park
    • Joori Park
    • Yoon Ki Kim
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • YTHDF2 has been extensively studied as an m6A-related RNA metabolism. Here, the authors show that YTHDF2 also contributes to protein homeostasis in an m6A-independent manner by promoting the formation of aggresomes through its interaction with UPF1.

    • Hyun Jung Hwang
    • Tae Lim Park
    • Yoon Ki Kim
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • The autophagy adapter p62/SQSTM1 plays a key role in selective autophagy and also recognizes N-end rule substrates. Here the authors provide molecular insights into p62 N-end rule substrate recognition by solving the structures of the p62 ZZ-domain in complex with various type 1 and type 2 degrons and also show the pH dependent oligomerization of p62.

    • Do Hoon Kwon
    • Ok Hyun Park
    • Hyun Kyu Song
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Our study highlights the decline of UPF1, a key component of nonsense-mediated mRNA decay (NMD), during cellular senescence and its impact on NMD efficiency, leading to the accumulation of aberrant mRNAs.

    • Dahyeon Koh
    • Yebin Lee
    • Kyoung Mi Kim
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-13