Nature Search

Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells

The xylosyltransferase isoenzymes XT1 and XT2 catalyze the first glycosylation step in the biosynthesis of proteoglycans. Now, bump-and-hole engineering of XT1 and XT2 enables substrate profiling and modification of proteins as designer proteoglycans to modulate cellular behavior.

Zhen Li
Himanshi Chawla
Benjamin Schumann
ResearchOpen Access20 Jan 2026
Nature Chemical Biology

P: 1-10
Initial skin necrosis presentation at emergency room was associated with fulminant clinical course and mortality in patients with Vibrio necrotizing fasciitis

Chun-Yuan Hsiao
Tsung-Yu Huang
Shu-Fang Kuo
ResearchOpen Access27 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
Kynurenic acid attenuates multiorgan dysfunction in rats after heatstroke

Yi-chang Hsieh
Ruei-feng Chen
Sheng-hsien Chen
Research04 Feb 2011
Acta Pharmacologica Sinica

Volume: 32, P: 167-174
Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2

Low level of pyruvate kinase M2 (PKM2) activity in cancer cells is essential for the dependence on aerobic glycolysis. Here the authors show that PKM2 sulfhydration by hydrogen sulfide destabilizes the PKM2 tetramer, leading to reduced PKM2 enzyme activity and enhanced proliferation of breast cancer cells.

Rong-Hsuan Wang
Pin-Ru Chen
Kai-Ti Lin
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-18
A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions

Yi-Chang Zhao
Yu-kun Zhang
Miao Yan
ResearchOpen Access21 Feb 2025
Scientific Reports

Volume: 15, P: 1-13
Results of streamlining TAVR procedure towards a minimalist approach: a single center experience in Taiwan

Tsung-Yu Ko
Hsien-Li Kao
Mao-Shin Lin
ResearchOpen Access06 Nov 2023
Scientific Reports

Volume: 13, P: 1-7
Impact of early failure of induction on transplant outcomes in Hodgkin lymphoma

Yu-Sung Chang
Wan-Chen Hsieh
Tai-Chung Huang
Correspondence18 Dec 2025
Bone Marrow Transplantation

P: 1-3
Genomic insights into the formation of human populations in East Asia

Genome-wide data from 166 East Asian individuals dating to between 6000 bc and ad 1000 and from 46 present-day groups provide insights into the histories of mixture and migration of human populations in East Asia.

Chuan-Chao Wang
Hui-Yuan Yeh
David Reich
Research22 Feb 2021
Nature

Volume: 591, P: 413-419
Comparison of intuitive assessment and palliative care screening tool in the early identification of patients needing palliative care

Yung-Feng Yen
Hsiao-Yun Hu
Chin-Yu Ho
ResearchOpen Access23 Mar 2022
Scientific Reports

Volume: 12, P: 1-8
Freestanding Three-Dimensional CuO/NiO Core–Shell Nanowire Arrays as High-Performance Lithium-Ion Battery Anode

Yin-Wei Cheng
Chun-Hung Chen
Chuan-Pu Liu
ResearchOpen Access21 Dec 2018
Scientific Reports

Volume: 8, P: 1-10
Previously published drug interaction models predict loss of response for transoesophageal echocardiography sedation well but not response to oesophageal instrumentation

Fu-Wei Su
Chien-Kun Ting
Shen-Chih Wang
ResearchOpen Access07 Mar 2019
Scientific Reports

Volume: 9, P: 1-8
COVID-19 in persons with chronic myeloid leukaemia

Weiming Li
Danyu Wang
Qian Jiang
Research18 May 2020
Leukemia

Volume: 34, P: 1799-1804
Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90

Kuei-Hung Lai
Yi-Chang Liu
Mei-Chin Lu
ResearchOpen Access31 Oct 2016
Scientific Reports

Volume: 6, P: 1-14
Expression of parvin-β is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract

C-F Wu
K-F Ng
S-T Pang
ResearchOpen Access24 Aug 2010
British Journal of Cancer

Volume: 103, P: 852-860
A comparative analysis of aerosol exposure and prevention strategies in bystander, pre-hospital, and inpatient cardiopulmonary resuscitation using simulation manikins

Tzu-Yao Hung
Chung-Shiung Wen
Tee Lin
ResearchOpen Access02 Aug 2023
Scientific Reports

Volume: 13, P: 1-10
Bio- chemical and physical characterizations of mesenchymal stromal cells along the time course of directed differentiation

Yin-Quan Chen
Yi-Shiuan Liu
Oscar K. Lee
ResearchOpen Access16 Aug 2016
Scientific Reports

Volume: 6, P: 1-12
Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Chun-Ting Cheng et al. demonstrate that arginine starvation kills arginine-auxotrophic cancer cells by depleting them of aspartate through asparagine synthetase (ASNS) and disrupting their mitochondrial metabolism. This study presents ASNS-induced aspartate depletion as an anti-cancer therapeutic strategy.

Chun-Ting Cheng
Yue Qi
David K. Ann
ResearchOpen Access26 Oct 2018
Communications Biology

Volume: 1, P: 1-15
Stem cell transplant for mantle cell lymphoma in Taiwan

Yu-Hung Wang
Ching-Yun Hsieh
Bor-Sheng Ko
ResearchOpen Access05 Apr 2022
Scientific Reports

Volume: 12, P: 1-11
Association between long-term usage of acetylcholinesterase inhibitors and lung cancer in the elderly: a nationwide cohort study

Chien-Ting Liu
Chuan-Chi Yang
Nian-Sheng Tzeng
ResearchOpen Access03 Mar 2022
Scientific Reports

Volume: 12, P: 1-8
USP24 promotes drug resistance during cancer therapy

Shao-An Wang
Ming-Jer Young
Jan-Jong Hung
ResearchOpen Access12 Apr 2021
Cell Death & Differentiation

Volume: 28, P: 2690-2707
m⁶A promotes R-loop formation to facilitate transcription termination

Xin Yang
Qian-Lan Liu
Yun-Gui Yang
Correspondence12 Oct 2019
Cell Research

Volume: 29, P: 1035-1038
Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model

L-S Chen
M Wang
D Chang
Research22 Apr 2010
Gene Therapy

Volume: 17, P: 1033-1041
High rate of invasive fungal infections after non-T cell depleted haploidentical allo-HSCT even under antifungal prophylaxis

Ming-Yu Lien
Su-Peng Yeh
Bor-Sheng Ko
Correspondence29 Mar 2021
Bone Marrow Transplantation

Volume: 56, P: 1750-1753
Detection and characterization of mineralo-organic nanoparticles in human kidneys

Tsui-Yin Wong
Cheng-Yeu Wu
John D. Young
ResearchOpen Access26 Oct 2015
Scientific Reports

Volume: 5, P: 1-13

Search

Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells

Initial skin necrosis presentation at emergency room was associated with fulminant clinical course and mortality in patients with Vibrio necrotizing fasciitis

Kynurenic acid attenuates multiorgan dysfunction in rats after heatstroke

Hydrogen sulfide coordinates glucose metabolism switch through destabilizing tetrameric pyruvate kinase M2

A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions

Results of streamlining TAVR procedure towards a minimalist approach: a single center experience in Taiwan

Impact of early failure of induction on transplant outcomes in Hodgkin lymphoma

Genomic insights into the formation of human populations in East Asia

Comparison of intuitive assessment and palliative care screening tool in the early identification of patients needing palliative care

Freestanding Three-Dimensional CuO/NiO Core–Shell Nanowire Arrays as High-Performance Lithium-Ion Battery Anode

Previously published drug interaction models predict loss of response for transoesophageal echocardiography sedation well but not response to oesophageal instrumentation

COVID-19 in persons with chronic myeloid leukaemia

Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90

Expression of parvin-β is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract

A comparative analysis of aerosol exposure and prevention strategies in bystander, pre-hospital, and inpatient cardiopulmonary resuscitation using simulation manikins

Bio- chemical and physical characterizations of mesenchymal stromal cells along the time course of directed differentiation

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Stem cell transplant for mantle cell lymphoma in Taiwan

Association between long-term usage of acetylcholinesterase inhibitors and lung cancer in the elderly: a nationwide cohort study

USP24 promotes drug resistance during cancer therapy

m⁶A promotes R-loop formation to facilitate transcription termination

Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model

High rate of invasive fungal infections after non-T cell depleted haploidentical allo-HSCT even under antifungal prophylaxis

Detection and characterization of mineralo-organic nanoparticles in human kidneys

Search

Quick links

Search

Filter By:

Search

Quick links