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Showing 1–7 of 7 results

Advanced filters: Author: Yi-Han Cao Clear advanced filters

Targeting thymine DNA glycosylase induces synthetic lethality in p53-deficient cancers

Thymine DNA glycosylase (TDG) was identified as a synthetic-lethal target in p53-deficient cancers through alterations in double-stranded RNA accumulation. A covalent small-molecule inhibitor of TDG exhibited potent efficacy against p53-deficient tumors.

Jia-Xin Zhou
Zhen-Yu Shao
Ya-Rui Du
Research22 Jan 2026
Nature Chemical Biology

P: 1-11
SNAP25-dependent membrane trafficking of the Kv1.5 channel regulates the onset of atrial fibrillation

While SNAP25 is critical for neural electrical communication, its cardiac role is unknown. Here the authors show that it governs atrial electrical stability by directing Kv1.5 channel trafficking, with therapeutic implications for atrial fibrillation.

Xuling Su
Beihua Shao
Yi-Han Chen
ResearchOpen Access19 Apr 2025
Nature Communications

Volume: 16, P: 1-14
A review of advances & potential of applying nanomaterials for biofilm inhibition

Yi-Han Cao
Wen-Jun Cai
Jianfeng Zhou
ReviewsOpen Access20 Dec 2024
npj Clean Water

Volume: 7, P: 1-21
Glutamate drives ‘local Ca²⁺ release’ in cardiac pacemaker cells

Duanyang Xie
Ke Xiong
Yi-Han Chen
ResearchOpen Access15 Jul 2022
Cell Research

Volume: 32, P: 843-854
Roundabout homolog 1 inhibits proliferation via the YY1-ROBO1-CCNA2-CDK2 axis in human pancreatic cancer

Qun Chen
Peng Shen
Jing-Jing Zhang
Research13 Mar 2021
Oncogene

Volume: 40, P: 2772-2784
Quaternary climate change drives allo-peripatric speciation and refugial divergence in the Dysosma versipellis-pleiantha complex from different forest types in China

Yi-Han Wang
Hans Peter Comes
Ying-Xiong Qiu
ResearchOpen Access11 Jan 2017
Scientific Reports

Volume: 7, P: 1-13
Memantine targets glutamate receptors in atrial cardiomyocytes to prevent and treat atrial fibrillation

Duanyang Xie
Ke Xiong
Yi-Han Chen
CorrespondenceOpen Access02 Aug 2022
Cell Discovery

Volume: 8, P: 1-4