Glutamate NMDA receptors are involved in pain signaling, but inhibiting them would have too many side effects. These authors show that inhibiting the binding of NMDA receptors to Src, a molecule that is resposible for amplifying glutamate signaling, reduces inflammatory and neuropathic pain in mice and rats (pages 1313–1315).
- Xue Jun Liu
- Jeffrey R Gingrich
- Michael W Salter
