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Advanced filters: Author: Yiao Jiang Clear advanced filters

Structural insights into GM4951 as a lipid droplet GTPase regulating hepatic lipid metabolism

GM4951 is a GTPase in hepatic lipid metabolism. Here, the authors determine the atomic structure of GM4951, which forms a tail-to-tail dimer essential for lipid droplet localization. MASLD-linked mutations destabilize the protein and alter the dynamics of switch loops of the GTPase domain.

Rishi Raj
Yiao Jiang
Bruce Beutler
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-18
Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2

Regulation of lipid metabolism by Hedgehog signalling is found to be mediated by a long non-coding RNA, named Hilnc, which can enhance Pparγ mRNA stability via the mRNA-binding protein IGF2BP2, and thereby affect obesity and liver steatosis.

Yiao Jiang
Jiayin Peng
Yun Zhao
Research08 Nov 2021
Nature Metabolism

Volume: 3, P: 1569-1584
KBTBD2 controls bone development by regulating IGF-1 signaling during osteoblast differentiation

Yu Xun
Yiao Jiang
Zhao Zhang
Research19 Nov 2024
Cell Death & Differentiation

Volume: 32, P: 1099-1111
Identification of a rare Gli1⁺ progenitor cell population contributing to liver regeneration during chronic injury

Jiayin Peng
Fei Li
Yun Zhao
ResearchOpen Access01 Nov 2022
Cell Discovery

Volume: 8, P: 1-18
LAMTOR5-AS1 regulates chemotherapy-induced oxidative stress by controlling the expression level and transcriptional activity of NRF2 in osteosarcoma cells

Youguang Pu
Yiao Tan
Dabing Huang
ResearchOpen Access03 Dec 2021
Cell Death & Disease

Volume: 12, P: 1-15