The construction of diversified compound libraries from identical substrates is attractive but remains a challenge in asymmetric synthesis. Here, we demonstrate switchable regioselective [6+2], [4+2] or [2+2] cycloadditions with α′-alkylidene-2-cyclopentenones via mild aminocatalysis, producing a spectrum of chiral frameworks with high structural diversity and molecular complexity.
- Zhi Zhou
- Zhou-Xiang Wang
- Ying-Chun Chen
