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Cryo-EM structures of Candida albicans Cdr1 reveal azole-substrate recognition and inhibitor blocking mechanisms

Candida albicans Cdr1 pumps azole antifungal drugs out of the cell, driving drug resistance. Here, the authors determine the mechanism of Cdr1-mediated fluconazole resistance and milbemycin oxime inhibition, providing a foundation for future drug discovery efforts.

Ying Peng
Yan Lu
Zhaofeng Yan
ResearchOpen Access06 Sept 2024
Nature Communications

Volume: 15, P: 1-11
Text complexity and translation styles from the perspective of individuation: a case study of the English translations of Pipa Xing

Yingchen Yu
Chenguang Chang
ResearchOpen Access23 Jan 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-17

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Cryo-EM structures of Candida albicans Cdr1 reveal azole-substrate recognition and inhibitor blocking mechanisms

Text complexity and translation styles from the perspective of individuation: a case study of the English translations of Pipa Xing

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